Objective: To prove high serum S100B protein levels as a predictor of impaired cognitive function in patients with moderate traumatic brain injury. Method: A prospective cohort analytic observational study. The subjects are patients with a moderate degree of TBI with inclusion criteria: onset of TBI 24 hours, age 17-40 years old, and the exclusion criteria were the presence of impaired cognitive function pre-traumatic brain injury (Short IQCODE) 3), depression and multiple trauma. Patients/families/guardians who agreed to the informed consent were checked for S100B levels at <24 hours, then matched with the Montreal Cognitive Assessment version Indonesia (MoCA-INA) questionnaire on day 14 after TBI. This study’s data analysis consisted of univariate and bivariate analysis using Chi-Square. The significance level is stated with p <0.05, 95% confidence interval (CI) assisted by the IBM SPSS version 23. Results: There were 43 research subjects; 23 in the high S100B group and 20 in the S100B group were not high. The mean age is 28 years, with a ratio of 4:1 for men and females. Most of the years, education ≥12 years. The incidence of cognitive dysfunction in patients with moderate traumatic brain injury in the high serum S100B group was 76.19%, while in the non-high serum S100B group was 23.80%, with RR = 6.85, with 95% CI between 1.78-26 .36, and p-value = 0.005. Conclusion: High serum S100B protein levels as a predictor of cognitive function disorders were statistically significant in moderate traumatic brain injury patients with a risk of 6.85 times.

Background/aim: Traumatic Brain Injury (TBI) is a neurological emergency. When a traumatic brain injury occurs, there will be short-term and long-term effects that will affect the brain. This study was aimed to determine the correlation of bleeding volume and cognitive function impairment in hemorrhagic traumatic brain injury. Method: This study uses data collection methods in the form of interviews with samples which will later be presented in the form of analytical observational study. Consecutive data collection on TBI patients in poly and unit room medical neurosurgery at Sanglah Hospital from August – Oktober 2021. The questionnaire used to cognitive function impairment with Montreal Cognitive Assessment version Indonesia (MoCA-INA). Data analysis using SPSS Version 23 for windows. Results: A total of 42 subjects were divided into normal and decreased cognitive function The patients’ mean age was average 29 (17-49) years old, Man 62%, cases epidural hemorrhagic 50 %, subdural 38% and intracerebral 12%, and their mean Glasgow Coma Scale score at admission was 11.5 ± 1.7 and significant with OR = 0.1 (95% CI = (0.02-0.4; p = 0.003) were. Lesions were predominantly localized to the frontal (14 lesions) and temporal (10 lesions) lobes. Lobe lesion volume did not correlate with cognitive function. The volume bleeding average 10.43 (1-40) significant with p= 0.016 (OR 5.2 (95% CI (1.3-19.7). Conclusion: Bleeding volume in hemorrhagic TBI increased five times in volume > 10 mL and GCS 9-13 first times came emergency room significant increased 0.1 times decreased function cognitive. Keywords: sleep quality, non-vegetarian, diet, serotonin, vegetarian

Background: Complications microangiopathy in the field of nerves resulting from diabetes mellitus is diabetic neuropathy. Patients with diabetes mellitus with blood glucose levels that are not regulated well have a 25.6% risk of developing neuropathy. Neuropathy can be diagnosed clinically, the presence of complaints such as numbness, tingling, or burning in the distal extremity, but almost half of patients are asymptomatic, other methods to determine the presence of neuropathy are questionnaires and electrodiagnostic examinations which are the gold standard. The purpose of this study was to find the relationship between the amplitude of nerve conduction velocity (NCV) with controlled and uncontrolled diabetes mellitus based on HBA1c in patients with peripheral diabetic polyneuropathy at Sanglah Hospital. Method: This study was conducted with a case-control analytic design at Sanglah Hospital by taking data retrospectively where patient data were directly taken from January 2021-October 31 2021 Results: There were 40 research subjects where 20 subjects with controlled DM and 20 subjects with uncontrolled DM, 62.5% men, with an age range of 50-60 years, BMI obesity, duration of diagnosis > 3 years where the results obtained were peripheral polyneuropathy conditions. with the results of NCV only found a significant difference in CMAP N Median with p 0.026 and in SNAP with p = 0.035 in SNAP Conclusion: All patients have the result of decreased function of NCV with the highest risk if it is not controlled with HBA1C levels < 7%, there will be the greatest decrease in NCV motor and sensory N. radialis. Keywords: diabetes mellitus, CMAP, HBA1C, NCV, SNAP.