Introduction: Infertility is the inability to get pregnant after 12 months or more without using contraception and is primary where the couple fails to get a pregnancy to continue the offspring. Infertility can be caused by factors of women, men or both. Around 50-80 million couples experience infertility in the world, infertility in developing countries is higher, which is around 30%, compared to developed countries, only 5-8%. Method: This research is a cross-sectional descriptive study. The source of the data comes from secondary data, namely medical records of patients experiencing infertility at the clinic visiting Sanglah Hospital for the period January 2016-December 2017. Data collection was taken by the Total Sampling method. The distribution of research variables is in women with tubal, uterine and ovarian factors whereas in men it is sperm factor. Result: Infertility events at Sanglah General Hospital Denpasar in January 2016-December 2017 were 38 cases. In women, the factor of one non-patent tube were 4 cases (25.0%), and respondents with both non-patent tubes were 12 cases (75.0%). Ovarian factor abnormalities, Endometrioma were 2 cases (12.5%). There were no cases of Uterine factor abnormalities in Women. Infertility in men based on sperm factors: 1 case oligozoospermia (5.6%), Asthenozoospermia 2 cases (11.1%), Teratozoospermia 1 case (5.6%), Oligo Astheno Teratozoospermia 11 cases (61.1%) and Azoospermia 3 cases (16.7%). Conclusion: The highest factor of infertility in women is abnormalities in the tube, both tubal non-patent. The highest cause of infertility in men is an abnormality in sperm, Oligo-Astheno-Teratozoospermia.