Background: Dengue infection is the most common mosquito-borne disease in Indonesia. Dengue incidence during pregnancy increases with its prevalence among women of reproductive ages. It potentially causes serious maternal and neonatal morbidity and mortality; however, its impact during a period of disease outbreak has not been described. We aimed to assess the outcomes of pregnancies affected by dengue infection during an outbreak in an endemic area of Indonesia. Methods: We conducted a prospective observational study at Sanglah General Hospital, Bali, Indonesia from April 2016 to April 2017. All pregnant women with clinical symptoms of dengue infection who tested positive for dengue nonstructural protein 1-antigen or anti-dengue immunoglobulin M were included in the study. Clinical features and hematological and biochemical parameters were documented to assess their relationship with maternal and neonatal outcomes. Results: Our study population consisted of 41 pregnant women. Most were multigravida (58.5%). Dengue infection without warning signs was observed in 31.7% of the cases, while 53.7% had dengue infection with warning signs, and 14.6% had dengue shock syndrome/severe dengue infection. Most pregnancies were in the third trimester (78%); five cases (12.2%) suffered clinical complications. Preterm delivery was observed in seven cases (17.1%). Most patients (75.6%) decided to seek medical treatment at a critical phase of dengue infection (days 3-6). Conclusion: The high incidence of associated morbidity and mortality should warrant clinicians in endemic regions to consider diagnoses of dengue infection when treating pregnant women with clinical signs and symptoms. Patients should be treated at centers with adequate resources for monitoring and emergency procedures. A more intensive study is needed in the future aiming to make a more comprehensive guideline.

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Introduction: Infertility is the inability to get pregnant after 12 months or more without using contraception and is primary where the couple fails to get a pregnancy to continue the offspring. Infertility can be caused by factors of women, men or both. Around 50-80 million couples experience infertility in the world, infertility in developing countries is higher, which is around 30%, compared to developed countries, only 5-8%. Method: This research is a cross-sectional descriptive study. The source of the data comes from secondary data, namely medical records of patients experiencing infertility at the clinic visiting Sanglah Hospital for the period January 2016-December 2017. Data collection was taken by the Total Sampling method. The distribution of research variables is in women with tubal, uterine and ovarian factors whereas in men it is sperm factor. Result: Infertility events at Sanglah General Hospital Denpasar in January 2016-December 2017 were 38 cases. In women, the factor of one non-patent tube were 4 cases (25.0%), and respondents with both non-patent tubes were 12 cases (75.0%). Ovarian factor abnormalities, Endometrioma were 2 cases (12.5%). There were no cases of Uterine factor abnormalities in Women. Infertility in men based on sperm factors: 1 case oligozoospermia (5.6%), Asthenozoospermia 2 cases (11.1%), Teratozoospermia 1 case (5.6%), Oligo Astheno Teratozoospermia 11 cases (61.1%) and Azoospermia 3 cases (16.7%). Conclusion: The highest factor of infertility in women is abnormalities in the tube, both tubal non-patent. The highest cause of infertility in men is an abnormality in sperm, Oligo-Astheno-Teratozoospermia.

Cervical partial hydatidiform mole is a rare condition and difficult to diagnose. A 39-year-old Balinese woman from Sanglah General Hospital, Bali, Indonesia complained vaginal bleeding with abdominal pain. The patient was diagnosed with a partial hydatidiform mole based on physical examination, ultrasound, beta HCG levels and pathology examinations. Mass evacuation surgery followed by arterial ligation to stop the bleeding and periodically examination of beta HCG levels was carried out until the 14th week after the procedure. Beta HCG decreased gradually to normal level and indicate no risk of trophoblastic malignancy. Establishing the early diagnosis significantly affects the outcome of patient. Keywords: partial cervical hydatidiform mole, blighted ovum, pregnancy, diagnosis, therapy.