PurposeHypertension is a key determinant for the development and progression of chronic kidney disease (CKD). The purpose of this study is to assess the rate of uncontrolled blood pressure (BP) and identify its associated factors in patients with predialysis CKD in Bali, Indonesia.Design/methodology/approachA cross-sectional study was conducted among 165 patients who attended the nephrology clinic in a central public hospital in Bali. Data were obtained by measuring BP at threshold 130/80 mmHg, as well as collected through standardized questionnaires. Univariate analysis was done using Chi-square test, and multivariate analyses were carried out using multiple logistic regression.FindingsA total of 165 patients (111 males and 54 females) with predialysis CKD participated in this study. About 64% of the participants had uncontrolled BP. In multiple logistic regression, all selected variables significantly explained 63.2% of the variance in uncontrolled BP. However, low physical activity (odds ratio [OR] = 24.287, 95% confidence interval [CI]: 3.114–189.445), unhealthy dietary pattern (OR = 10.153, 95% CI: 2.770–37.210), as well as perceived moderate stress (OR = 4.365, 95% CI: 1.024-18.609) and high stress (OR = 10.978, 95% CI: 2.602–46.312) were significantly associated with uncontrolled BP.Research limitations/implicationsThe study findings provide evidence for health care providers to improve BP control among patients with predialysis CKD.Originality/valueControlling BP among patients with predialysis CKD was poor. Lifestyle modification and stress management are keys to improving BP control.

Abstract.This study aimed to analyze the effectiveness Problem Based Learning toward Biology learning outcomes in the subject of Basic Nursing Science I. The research design was true experimental design. The population in this study was the first-grade students in Nursing Sciences Study Program in Sekolah Tinggi Ilmu Kesehatan Bali. Purposive sampling technique was applied to select the sample size in experimental and control group. There were 162 respondents included in this study. The data were analyzed using descriptive statistic and independent sample TTest. The result showed that the average of post-test in control group was 67.01 ± 7.53 and average of post-test in the experimental group was 80.16 ± 5.92 (p < 0.05). It could be concluded that Problem Based Learning Model is more effective than a conventional model. It can be used for the alternative model in learning which can improve student's ability in critical thinking and the learning outcomes of Biology in subject Basic Nursing Science I.

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This study aims to determine the antioxidant potential of Balinese salak rind extract (Salacca amboinensis (Becc) Mogea) (BSRE) as an antihyperglycemic agent in male white mice with hyperglycemia. The research was conducted in three stages extraction of Balinese salak rind using 96% ethanol, phytochemical screening, and antihyperglycemic activity testing. Mice were hyperglycemia induced by alloxan. Mice were divided into five groups consisting of negative control (Aquadest), positive control (Glibenclamide 13 mg/Kg BW), dose 1 (200 mg BSRE/kg BW), dose 2 (400 mg BSRE/kg BW), dose 3 (600 mg BSRE/kg BW). Phytochemical screening showed that the BSRE was positive for containing alkaloids, flavonoids, tannins, saponins, and steroids. The analysis results on the BSRE showed an IC50 value of 81,76 ppm, including strong antioxidant activity. The activity of blood glucose levels showed that BSRE could decrease blood glucose levels of Mus musculus L. with hyperglycemia.

Pendahuluan: Chronic kidney disease (CKD) merupakan salah satu penyebab utama buruknya pencapaian hasil kesehatan. Di Indonesia, angka kasus CKD juga semakin meningkat tidak hanya dikalangan lansia maupun dewasa namun juga di kalangan remaja. Penelitian juga menemukan bahwa saat ini remaja hingga dewasa muda mulai memiliki risiko tinggi terhadap kejadian CKD. Perubahan gaya hidup banyak remaja dan dewasa muda yang mana mengarah ke tidak sehat dapat menjadi pencetus meningkatnya kasus CKD dimasa yang akan datang. Metode: Penelitian ini menggunakan metode descriptive cross sectional dengan rancangan penelitian non eksperimental. Pengolahan data dengan analisis data bivariat dengan Spearman’s rho. Penelitian dilakukan secara daring yang dilaksanakan pada bulan April 2020 dengan jumlah 423 responden mahasiswa perawat di ITEKES Bali. Hasil: Hasil penelitian terdapat hubungan yang signifikan antara pengetahuan dan perilaku pencegahan mahasiswa tentang CKD dengan nilai p-value > 0.05. Kesimpulan: Hal ini mengindikasikan semakin baik tingkat pengetahuan mahasiswa mengenai CKD, maka semakin positif pula perilaku pencegahan mahasiswa terhadap kejadian CKD.