Of the currently limited available data on the mental health of students in Ireland the most notable are provided in the College Lifestyle and Attitudinal National (CLAN) Survey (Hope, Dring, & Dring, 2005). Recently, Houghton et al. (2012) found among students at an Irish university that women reported significantly higher levels of symptomatology than men on each of the three 6-item subscales of the Brief Symptom Inventory 18 (BSI 18; Derogatis, 2001) (anxiety, depression, and somatization) and the Global Severity Index (GSI; summed total of the 18 items). Similarly, final-year students had significantly worse mental health than non-final-year students. Internal reliability, construct validity, and factor structure of the BSI 18, were reported but no data on the test-retest reliability of the measure. Our aim was to supplement these findings by reporting on the test-retest reliability of the BSI 18 in a small sample of Irish college students.
SUMMARY
Lithium is a gold standard maintenance treatment in bipolar affective disorder. It has a narrow therapeutic range, and at higher serum lithium levels there is a risk of adverse effects and toxicity. There are three patterns of lithium intoxication: acute, acute-on-chronic and chronic. We describe risk factors for lithium intoxication, mechanisms of toxicity and clinical symptoms seen in lithium intoxication. We describe both the acute and chronic effects of lithium toxicity. Lithium intoxication may be life-threatening and associated with longer-term sequelae. The management of lithium intoxication involves determining the type of intoxication. We discuss treatment strategies aimed at reducing absorption and increasing elimination of lithium. We discuss clinical indications for extracorporeal methods such as dialysis, which are used to limit the time and degree of exposure of the central nervous system to toxic lithium concentrations. Haemodialysis is the most rapid method of eliminating lithium from the body, but careful monitoring is required. Preventive strategies to mitigate the risk for lithium intoxication are discussed.
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