No abstract

Both L-( > 95% e.e.) and D-(60% e.e.) 4hydroxy-2-ketoglutarate 3 have been prepared on a mmol scale using 4hydroxy-2-ketoglutarate (H KG) aldolase. Substrate specificity studies indicate that H KG aldolase isolated from different sources (Escherichia coli, bovine liver and rat liver) is highly specific for both pyruvate and glyoxylate.

Beauveria sulfurescens ATCC 7159 oxidized the N-arylamines 3, 4, 7, 13, 18, 20, 22 at the 4position with good selectivity and in 3666% yield.

1993 biochemical syntheses, microbiological syntheses biochemical syntheses, microbiological syntheses O 0035 34 -062 Biooxidations of Some N-Arylpiperidines and Related Compounds Using Beauveria sulfurescens. -B. sulfurescens ATCC 7159 oxidizes 4'-substituted N-arylpiperidines (I) and related compounds (8 examples in all) at the 4-position with excellent selectivity and good yields. -(FLOYD, N.; MUNYEMANA, F.; ROBERTS, S. M.; WILLETTS, A. J.; J. Chem. Soc., Perkin Trans. I (1993) 8, 881-882; Dep. Biol. Sci., Univ. Exeter, Exeter, Devon EX 4 4QD, UK; EN)

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