No abstract

A two-dimensional west coast tidal model, built on the ADCIRC platform (an unstructured grid twodimensional depth-integrated shallow water model), has been developed to examine the scope for reliable and fully predictable electricity generation from UK coastal waters using an ambitious combination of estuary barrages, tidal lagoons and tidal stream generator arrays. The main emphasis has been towards conjunctive operation of major estuary barrages, initially including the presence of pilotscale tidal stream developments, though ambitious exploitation of extensive tidal streams has also been explored.

This paper describes the substantial potential of tidal barrage solutions for renewable energy generation in the UK. It demonstrates that installations on as few as eight major estuaries should be capable of meeting at least 10% of present electricity demand, and possibly significantly more, employing fully proven technology. This should be achievable, under favourable UK Treasury discount rates, at unit electricity prices that are likely to be competitive against future costs of alternative sources. This potential substantially exceeds that of 'tidal stream' turbine or practicable 'lagoon' systems, much vaunted in recent times. It also draws attention to a recent study investigating the tidal power potential in the north-west of England.

The paper includes a thorough charac-terisation of a technique called Purely Sinusoidal Voltammetry (PSV). This technique is usedto infer reaction parameters about a surface-linked redox process, and the characterisationeffort involves both computational and experimental methods.

<div><div><div><p>Site-selective chemical methods for protein bioconjugation have revolutionised the fields of cell and chemical biology through the development of novel protein/enzyme probes bearing fluorescent, spectroscopic or even toxic cargos. Herein we report two new methods for the bioconjugation of a-oxo aldehyde handles within proteins using small molecule aniline and/or phenol probes. The ‘a-oxo-Mannich’ and ‘catalyst-free aldol’ ligations both compete for the electrophilic a-oxo aldehyde which displays pH divergent reactivity proceeding through the “Mannich” pathway at acidic pH to afford bifunctionalised bioconjugates, and the “catalyst-free aldol” pathway at neutral pH to afford monofunctionalised bioconjugates. We explore the substrate scope and utility of both these bioconjugations in the construction of neoglycoproteins, in the process formulating a mechanistic rationale for how both pathways intersect with each other at different reaction pH.</p></div></div></div>