Thalassemia is inherited anemia publicity that common in the world and especially in Mediterranean region, and the most important cause of mortality in patients. The study included ( 108) patients (males & females) with thalassemia in Amara city and (20) healthy individuals as a control group. All subjected to examination tests for assessment hematological parameters as well as liver functions tests.The results showedasignificant increase(p<0.01) in glutamic pyruvic transaminase (GPT), glutamic oxaloacetic transaminase (GOT),andAlkaline Phosphatase (ALP) in patients with thalassemia compared with healthy subjects, however, total bilirubin concentration(TSB) did not show significant difference.There are also a significant increases (p <0.01) in White blood cells (WBC) and Platelets (PLT), While Red blood distribution width (RDW) in thalassemia patients compared with healthy subjects,Red blood cell (RBC), Mean cell volume (MCV), Mean corpuscular hemoglobin (MCH), Mean concentration of hemoglobin (MCHC),Hemoglobin (Hb) showed significant decrease (P <0.01) in thalassemia patients compared with healthy subjects. In conclusion: liver enzymes GPT, GOT, and ALP were significantly higher in thalassemia patients, hematological parameters were contradictive when compared with healthy subjects.

Helicobacter pylori are Gram-negative curved rods that habitats the gastric mucosa and considered as the leading causes of stomach ulcers and duodenal ulcers in humans. The main object of this study was to evaluate the influences of the bacteria on several hematological parameters. A total of 60 patients aged between 15 to 40 years were included in this study (30 male and 30 female) in addition to 30 healthy individuals from the same ages who were considered as a control group. Venous blood (4 ml) was obtained from the study population and investigated for complete blood count (CBC) using an automated hematology analyzer. The results revealed that there is a substantial decrease (p 0.01) in Hemoglobin (Hb), Red cell distribution width (RDW), and mean corpuscular hemoglobin (MCH) in patients compared to control. However, no significant difference in Red blood cells (RBCs), Hematocrit (HCT), mean corpuscular volume (MCV) and mean corpuscular hemoglobin concentration (MCHC) in patients compared to control. Also, no significant differences were found in the white blood cell (WBC) between H. pylori infected and non-infected persons. Otherwise, there are significant differences (p 0.01) in lymphocytes, monocytes, granulocytes in the patients and healthy individuals. The results also found that there are significant statistical differences in some of the hematologic parameters among study groups according to their gender. The study concluded that Hb, RDW, lymphocytes, monocytes, granulocytes are decreased in H. Pylori infected patients suggesting that infection may have direct effects on blood parameters.

Multi-transfused βthalassemia major patients still at high risk of acquiring blood-borne viruses just like hepatitis C (HCV), hepatitis B (HBV) and human immunodeficiency virus (HIV). To estimate the percent of HCV infection among multi-transfused βthalassemia major patients, a sample of (109) βthalassemia major patients were subjected to anti-HCV screening test using enzyme-linked fluorescent assay (ELFA) technique. The results revealed that 30 (27.5%) patients present + anti-HCV in Amara city. However, the infection rate was higher in the male gender than females and increased with age. The results also found that HCV infection is predominant in B+, O+, and A+ blood groups, moreover, a highly significant positive correlation detected between HCV infection and B+ blood group. The study concluded that there is an elevated rate of HCV infection among βthalassemia major patients, requiring more efficient viral screening techniques to the blood donors, the positive relationship between blood group and HCV infection suggests a role of gene-environment interaction and needing molecular studies to clarify such correlation.

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