COVID‐19 facts and literature are discussed into chemical science intuition highlighting the direct role of chemistry to the ongoing global pandemic by covering structural identification of the virus, chemical preventive measures and development of drugs. We reviewed the four most promising repurposed drugs which are presently being investigated in mass clinical trials on COVID‐19 infected persons and synthetic routes of these drugs with their recent advancement. Chemical preventive measures such as soap water, hand sanitizer and disinfectant are the only available options in the arsenal to fight against COVID‐19, till an effective medicine or vaccine will be made available. As such the present review will focus on the mode of action of the major chemical preventives.

Proper monomer design is the key to enhancing the strength of noncovalent interactions between the molecules toward the efficient formation of supramolecular polymers (SPs). We have designed and synthesized 1,n'disubstituted ferrocene-azobenzene-long alkyl chains, Fc-(CONH-Azo-TDP) 2 , to afford SPs with a high probability. The design exploits the ''molecular ball-bearing'' property of the ferrocene core, which allows two azobenzene arms to rotate in the planes of cyclopentadienyl rings, generating the most suitable molecular conformation required for SP formation.This ferrocene monomer formed a supergel consisting of SPs supported by strong intermolecular (H-bonding and π-π stacking) interactions and higher enthalpy gain than the reference molecules, where the central ferrocene core was replaced by flexible aliphatic as well as rigid benzene linkers. The molecular conformation involved in SPs, the strength of noncovalent interactions, and the process of supramolecular polymerization were investigated through NMR, UV-Vis, XRD and TEM studies. The results demonstrate that ferrocene may act as a good modulator for constructing efficient SPs.