Background: The most common and deadly cancers are lung cancer. There are no symptoms or indicators in its early stages. In study silver nanoparticles of Ginkgo biloba herb were synthesized and prepared solutions of different concentration of this nanoparticles compound, solution of different concentrations of the bilobetein compound which is the main compound in the ginkgo biloba herb. Objective: The purpose of this study was to prepare silver nanoparticles of ginkgo biloba herb and to study the effect of this compound at different concentration as an antifolate, through its reduction of the enzyme DHFR concentration Patient and Methods: This study was divided into three groups as following: thirty samples of blood serum from men and women as a control group with age range 23-45 years, thirty samples of blood serum from men and women of small cell lung cancer patients with age range 45-80 years and finally, thirty samples of blood serum from men and women of adenocarcinoma lung cancer patients with age range 45-80 years. Results:The 4 ppm concentration of the nanoparticles solution gave the best reduction in enzyme concentration in patients of small cell and adenocarcinoma lung cancer compared to control (465.94 ± 238.74 and 700.09 ± 324.59 vs 1680.38 ± 345.51 pg/ml). 8 ppm concentration showed reduction of enzyme concentration in small cell and adenocarcinoma lung cancer compared to control of 586.62 ± 225.57 and 1131.23 ± 415.33 vs 1860.06 ± 163.22 pg/ml. Conclusion: This study concluded the bilobetein and silver nanoparticle of Ginkgo biloba had the ability in preventing growth of cancer cells by reducing the DHFR concentration in sera of small and adenocarcinoma lung cancer patients.

Background: Experts consider pancreatic cancer one of the most deadly types. For unknown reasons, pancreatic cancer incidence and mortality are rising. Scopoletin and Ag-NPs compounds have therapeutic properties and are utilized experimentally in vitro as chemotherapies for numerous disorders.Objective: This study manufactures silver nanoparticles from fenugreek extract and analyzes their anti-metastatic effects with scopoletin at different doses to find the best combination to lower FAK enzyme concentration. Patient and Methodes: Sixty pancreatic cancer serum samples were divided: 30-Stage II patient samples (male and female, 45-65 years old), 30 stage IV patients of both sexes and ages (52-79), Thirty serum samples from healthy 23-45-years-olds served as a control group. Silver nanoparticles and scopoletin solutions were tested to find the appropriate concentration to reduce the focal adhesion kinase (FAK) enzyme. Resuts: Researchers showed that patients with stage ΙΙ and stage ΙΙΙ with pancreatic cancer and the control group had enzyme concentrations of 1.620.11ng/ml, 1.790.06 ng/ml, and 0.940.41 ng/ml, respectively, when treated with a 2 ppm solution of nanoparticles. Stage ΙΙ and stage ΙΙΙ with pancreatic cancer patients had lower enzyme concentrations than controls (1.570.15 ng/ml and 1.410.07 ng/ml). when treated with a 8 ppm solution of Scopoletin solution.Conclusion: Based on their potential to decrease focal adhesion kinase enzyme concentrations in the blood serum of patients with stageΙΙ and stageΙΙΙ Iraqi pancreatic cancer, scopoletin and silver nanoparticles of fenugreek can be recommended as anticancer materials.