To find out the association of serum homocysteine levels and serum vitamin B-12 levels in patients with retinal vein occlusion.Patients of all age group and any sex who are coming in vitreoretinal OPD of department of ophthalmology at a tertiary care hospital of Western Maharashtra were studied. 50 cases of RVO and same number of age and sex matched controls were taken into consideration. All patients were underwent for assay of serum homocysteine by ECLIA method and serum Vitamin B12 by CMIA method.The highest number of cases were of BRVO (60%) followed by CRVO (30%) and only one case of TVO (2%) was noted. The average level of homocysteine in RVO and control group is found to be 23.80 and 12.43 whereas the standard deviation of homocysteine level in RVO group is 13.28 and control group is 10.58. Therefore levels of homocysteine are significantly higher in RVO group in comparison with control group. Vitamin B-12 level was 455.86 in control group and 325.8 in RVO group. The P value suggests that, Vitamin B12 was significantly lower in case group compared to controls. Vitamin B-12 levels were significantly lower in cases with a higher Homocysteine level. Hype-rhomocysteinemia and hypovitaminosis B12 is significantly present in cases of retinal vein occlusion irrespective of types and underlying systemic diseases.

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