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I n t R o D U C t I o nReduced sperm fertility occurs on average in 7% of men in the population [2,7]. As a rule, laboratory and instrumental signs of male infertility are semen disorders that are quantitative and qualitative [2]. Male infertility is a polyetiological disease [1], which may be due to genetic factors. Genetic abnormalities are available azoospermia in 30-50% of patients [5,6,8].It is known that there are several genetic causes of male infertility: chromosomal disruptions (Robertson translocations, structural changes in the karyotype, inversions); abnormal number of chromosomes (chromosomal disomy, development of Klinefelter syndrome); the appearance of fallen chromosomal sites (deletions) in the AZF locus of the Y chromosome; microdeletions and point mutations in the androgen receptor (AR) gene; abnormalities in the structure of sex chromosomes (local mutations) [3,4]. Aim.Identify the main genetic causes of azoospermia. a B s t r a C t -Aim: To identify the main genetic causes of azoospermia. Methods. The study included 92 patients with azoospermia. In all patients we carried out genetic tests -karyotyping, PCRdiagnosis of blood. Results. Genetic disorders were found in 35 (38%) men. Of these, the majority of men were with Kleinfelter syndrome -21 (60%) and deletions in the AZF regions of the Y chromosome -11 (31.4%). Conclusions. Patients who have genetic abnormalities should receive comprehensive medical and genetic advice. K E Y w o r d s -Male infertility, azoospermia, chromosomal abnormalities, Kleinfelter syndrome, AZF microdeletions