A series of 2-substituted-5-methylbenzimidazole derivatives (3a-e) were synthesized by reacting 4-methyl-1,2-phenylenediamine (1) with a number of p-substituted benzaldehydes (2a-e) in moderate yields (25.51-40.21%). The synthesized compounds (3a-e) were characterized by spectroscopic data and were evaluated for antioxidant activity using DPPH free radical scavenging assay. The compounds showed significant antioxidant activity having IC50 value of 1.054-19.05 µg/ml as compared to the standard BHT (26.96 µg/ml).
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