Synthesis and Antioxidant Activity of Some Novel Benzimidazole Derivatives

Karmaker, Nilima; Lira, Dilshad Noor; Das, Biplab; Kumar, Uttom; Rouf, Abu Shara Shamsur

doi:10.3329/dujps.v16i2.35263

Cited by 17 publications

(7 citation statements)

References 8 publications

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“…This might be due to the direct antioxidant properties of both compounds or the activation of antioxidant defense machinery. The antioxidant capacity and free radical scavenging properties of benzimidazole derivatives were confirmed previously [ 68 , 69 ] and were reported to be associated with their structural features [ 70 ]. Taken together, we believe that treating pepper plants with HPBI or Al−HPBI complex might reduce the development of Fusarium wilt disease in pepper plants by directly increasing the antioxidant capacity within infected plants.…”

Section: Discussionsupporting

confidence: 70%

Benzimidazole Derivatives Suppress Fusarium Wilt Disease via Interaction with ERG6 of Fusarium equiseti and Activation of the Antioxidant Defense System of Pepper Plants

El-Nagar

Elzaawely

El-Zahaby

et al. 2023

JoF

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Sweet pepper (Capsicum annuum L.), also known as bell pepper, is one of the most widely grown vegetable crops worldwide. It is attacked by numerous phytopathogenic fungi, such as Fusarium equiseti, the causal agent of Fusarium wilt disease. In the current study, we proposed two benzimidazole derivatives, including 2-(2-hydroxyphenyl)-1-H benzimidazole (HPBI) and its aluminum complex (Al−HPBI complex), as potential control alternatives to F. equiseti. Our findings showed that both compounds demonstrated dose-dependent antifungal activity against F. equiseti in vitro and significantly suppressed disease development in pepper plants under greenhouse conditions. According to in silico analysis, the F. equiseti genome possesses a predicted Sterol 24-C-methyltransferase (FeEGR6) protein that shares a high degree of homology with EGR6 from F. oxysporum (FoEGR6). It is worth mentioning that molecular docking analysis confirmed that both compounds can interact with FeEGR6 from F. equiseti as well as FoEGR6 from F. oxysporum. Moreover, root application of HPBI and its aluminum complex significantly enhanced the enzymatic activities of guaiacol-dependent peroxidases (POX), polyphenol oxidase (PPO), and upregulated four antioxidant-related enzymes, including superoxide dismutase [Cu-Zn] (CaSOD-Cu), L-ascorbate peroxidase 1, cytosolic (CaAPX), glutathione reductase, chloroplastic (CaGR), and monodehydroascorbate reductase (CaMDHAR). Additionally, both benzimidazole derivatives induced the accumulation of total soluble phenolics and total soluble flavonoids. Collectively, these findings suggest that the application of HPBI and Al−HPBI complex induce both enzymatic and nonenzymatic antioxidant defense machinery.

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Section: Discussionsupporting

confidence: 70%

Benzimidazole Derivatives Suppress Fusarium Wilt Disease via Interaction with ERG6 of Fusarium equiseti and Activation of the Antioxidant Defense System of Pepper Plants

El-Nagar

Elzaawely

El-Zahaby

et al. 2023

JoF

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“…The result is hydrogen peroxide (H2O2) which is a non-radical oxidant. Furthermore, the radical Hydrogen peroxide (H2O2) will be neutralized by enzymatic antioxidants Gluthation peroxidase (GSH-Px) and catalase to be converted into water (H2O) and oxygen (O2) (Karmaker, Lira, Das, Kumar, & Rouf, 2017). Radicals Hydrogen peroxide (H2O2) can also react again with superoxide anion (O2•-) to hydroxyl radicals (OH-) called the Haber-Weiss reaction.…”

Section: Resultsmentioning

confidence: 99%

The Expression Change of Mmp-8 and Collagen Type-2 Intracell in Lung Tissue Due to Electronic Smoke Exposure

Suryadinata

Wirjatmadi

Andriani

et al. 2022

Kemas

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The number of electronic smokers has increased annually. Exposure to an electronic cigarette will increase free radicals in the body and result in oxidative stress causing lung tissue damage. The severity degree of lung tissue damage caused by electronic smoke exposure depends on the duration of electronic cigarette smoke exposure, and will affect Matrix Metalloproteinase-8 and collagen type-2 in the cells. The study aims to understand the change degree of Matrix Metalloproteinase-8 and collagen type-2in lung tissue due to electronic cigarette smoke exposure. This study applied the experimental method with a post control group design. The male Wistar rats were used as the animal models in this research to assess cell damage through the Matrix Metalloproteinase-8 expression and collagen type-2 in the lung tissue using immunohistochemical staining. Exposure to electronic smoke cigarettes was given to each group of animal models with the difference in amount and time duration. The expression of Matrix Metalloproteinase-8 indicated a significant increase due to electronic smoke exposure (ANOVA, p=0.000). Meanwhile the expression of collagen type-2 showed a significant decrease because of electronic smoke exposure (ANOVA, p=0.000). Besides, MMP-8 and collagen type-2 manifested relationship existence and strong impact (r=0.948, p=0.000). The negative impact of exposure to electric cigarette smoke causes increased expression of Matrix Metalloproteinase-8 and decreased expression of type-2 collagen in lung tissue.

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“…10i) [107][108]. Karmaker et al [109] reported the design of a series of benzimidazoles with nitro substituents which exhibited higher antioxidant than BHT. Watanabe and co-workers reported a rational design and clinical trials of novel antioxidant edaravone (3-methyl-1-phenyl-2-pyrazolin-5one) (Fig.…”

Section: Fig 9 5-hydroxypyrimidinementioning

confidence: 99%

Antioxidant Drug Design: Historical and Recent Developments

Egbujor

Egu

Okonkwo

et al. 2021

JPRI

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The sustained interest in the design of potent antioxidants drugs over the years can be attributed to the indispensable roles antioxidants play in the mitigation of oxidative stress and its concomitant diseases. The high demand for exogenous antioxidants has been ascribed to the prevalence of oxidative stress-mediated diseases such as cancer, diabetes, stroke, cell aging, arteriosclerosis and central nervous system disorders occasioned by a biochemical disequilibrium between the production of free radicals and the body’s ability to eliminate these reactive species from the biological system. COVID-19 severity and death have been linked to a free radical generating process known as the cytokine storm. In an attempt to maintain optimal body function, antioxidant supplementation has increasingly become a wide spread practice because of antioxidants’ ability to directly scavenge free radicals, inhibit oxidative chain reactions thereby increasing the antioxidant defenses of the body. Recent data showed that researchers had made significant efforts to demonstrate the importance and timeliness of antioxidant therapy based on drug design from natural and synthetic sources. Therefore this review presents antioxidant drug design methodologies, identifying the lead and hits to provide a historical and up-to-date collection of research briefs on antioxidant drug design into a single piece in order to ensure easy accessibility, motivate readership and inspire future researches.

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Synthesis and Antioxidant Activity of Some Novel Benzimidazole Derivatives

Cited by 17 publications

References 8 publications

Benzimidazole Derivatives Suppress Fusarium Wilt Disease via Interaction with ERG6 of Fusarium equiseti and Activation of the Antioxidant Defense System of Pepper Plants

Benzimidazole Derivatives Suppress Fusarium Wilt Disease via Interaction with ERG6 of Fusarium equiseti and Activation of the Antioxidant Defense System of Pepper Plants

The Expression Change of Mmp-8 and Collagen Type-2 Intracell in Lung Tissue Due to Electronic Smoke Exposure

Antioxidant Drug Design: Historical and Recent Developments

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