The viruses that infect humans cause a huge global disease burden and produce immense challenge towards healthcare system. Glycoproteins are one of the major components of human pathogenic viruses. They have been demonstrated to have important role(s) in infection and immunity. Concomitantly high titres of antibodies against these antigenic viral glycoproteins have paved the way for development of novel diagnostics. Availability of appropriate biomarkers is necessary for advance diagnosis of infectious diseases especially in case of outbreaks. As human mobilization has increased manifold nowadays, dissemination of infectious agents became quicker that paves the need of rapid diagnostic system. In case of viral infection it is an emergency as virus spreads and mutates very fast. This review encircles the vast arena of viral glycoproteins, their importance in health and disease and their diagnostic applications.

No abstract

No abstract

This paper presents a bond graph model of a free rail wheelset rolling on fleXible curved track, considering siX degrees of freedom without linearity approXimations. Modeling of engineering systems through bond graphs is based on eXchange of power amongst the basic elements of a system and several energy domains can be represented in a unified manner. In this paper, the modeling approach is based on creating subsystem bond graph models or capsules representing various analytical aspects of wheelset dynamics. The model is finally converted to a wheelset capsule, which can be further used for the development of truck and carbody models with suspension elements. The model can accommodate any creep force formulation for the rail—wheel contact forces. In this work, both Kalker's linear theory and heuristic modification based on non-linear formulation by Vermeulen and Johnson are used separately in a comparative study. Both these formulations allow the creep forces to be modeled by a non-linear bond graph R elements acted upon by the corresponding slip velocities between the wheel and track. Kinematic analysis of the wheelset is carried out to determine velocities of the contact points. The bond graph is created using software SYMBOLS 2000 and simulated for a set of parameter values.

An extensive investigation has been carried out to study structure-property characteristics and corrosion behavior in three varieties of thermomechanically treated (TMT) reinforcement bars (rebars) produced in an integrated steel plant under the Steel Authority of India Limited. Three experimental steel heats--one of plain-carbon and two of low-alloy chemistry--were chosen for the study. Of the two lowalloy heats, one was copper-bearing and the other contained both copper and chromium for improved corrosion resistance. Hot-rolled bars for each specific chemistry were subjected to in-line thermomechanical treatment, where quenching parameters were altered to achieve different yield strength levels.All the TMT rebars, regardless of chemistry and strength level, exhibited a composite microstructure consisting of ferrite-pearlite at the core and tempered martensite at the rim. Although a tendency toward formation of Widmanst/itten ferrite was evident in bars of 500 and 550 MPa yield strength levels, no adverse effect on their strength and ductility was observed. From the standpoint of mechanical properties, the rebars not only conformed to minimum yield strength requirements, but also exhibited high elongation values (21 to 28 %) and excellent bendability. Corrosion studies of both TMT and cold-twisted and deformed (CTD) rebars subjected to different laboratory tests indicated that corrosion resistance increased in this order: CTD, plain-carbon TMT, copper-bearing TMT, and copper/chromium-bearing TMT.