The quality of students is reflected in the quality of education. As a result, teachers must be persistent in achieving good and appropriate educational goals. This study aimed to determine the role of a growth mindset on grit in high school teachers in Purwokerto, Indonesia. This research is a quantitative study using a simple random sample sampling technique, which obtained 174 samples of high school teachers in Purwokerto. Data collection in this study used a growth mindset and a grit scale with a reliability coefficient of 0.895 for a growth mindset and 0.913 for grit. The analysis technique in this study uses simple linear analysis. The results showed that the value of F-test = 162.434 and T-test = 12.745 with a significance value (p) = 0.000 (p<005). The hypothesis in the study was accepted, namely that there was an influence between the growth mindset variable on grit. This study obtained a determinant coefficient or Rsquare of 0.486, implying that the influence of the growth mindset variable on the grit variable has an effective contribution of 48.6%. It can interpret as this influence that the perspective or belief held by the teacher will affect the persistence of effort and the consistency of interest held by the teacher. Further research can replicate the model on different populations of subjects with similar subject characteristics, such as kindergarten, elementary, junior high, or special education teachers who handle students.