Aim: To report the evolution of a de novo choroidal melanoma. Method: This is a case report of a 22-year-old white male patient who has been undergoing periodic examination for a choroidal ‘freckle' since 10 years of age. Results: In 2007, a fundus photograph of the left eye showed a nondescript area of choroidal hyperpigmentation temporal to the fovea. Progressive growth was observed and, by 2012, the lesion had become well circumscribed and raised. One year later, a 4.5 × 4.5 × 1.5 mm, dome-shaped, pigmented, choroidal mass with subretinal fluid and orange pigmentation was evident. The lesion was classified as a small choroidal melanoma. Six months after plaque radiotherapy, tumor regression with total resolution of the subretinal fluid was documented. Conclusion: The distinction between small choroidal melanoma and choroidal nevus is not absolute; therefore, some choroidal melanomas may initially be mislabeled as choroidal nevi because of their small size until continued growth identifies them to be small choroidal melanomas. In our case, the documented growth of the choroidal lesion on each consecutive visit and its high-risk features strongly suggest that it had been a melanoma from the beginning. To our knowledge, this is only the second documented case of a de novo evolution of a small choroidal melanoma. © 2014 S. Karger AG, Basel

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Rosa x damascena Herrm. represents one of the most popular and important plants of the Rosaceae family. For ages, rose oil, rose water and extracts from its flowers were used in perfumery, cosmetics, aromatherapy, and medicine due to diverse pharmacological efficacy. Nowadays, special attention is paid to the valorization of wastes from the rose oil industry in order to fully recover potent biologically active compounds. The present study describes in detail the microstructural features of the flower petals and provides data on chemical composition and biological potency of the aqueous extract of rose oil waste from the R. damascena Georgian cultivar. Up to 25 constituents were detected by HPLC-MS in the extract, and the content of total flavonoids in the extract reaches 2.29%. Amongst them hyperoside is dominating, which content is not less than 1%. Pharmacological evaluation of the extract on "Hot plate" and carrageenan-induced oedema models in mice revealed analgesic (42%) and anti-inflammatory (67%) effects of the extract. As well, the extract revealed antiplasmodial activity against Plasmodium falciparum (3D7) strain (IC50 =20.31 µg/mL)