Study design: A quantitative cross-sectional survey study. Objective To determine the knowledge, attitude and practice (KAP) among caregivers regarding prevention and care of pressure ulcer in patients with spinal cord injury and relationship between KAP. Setting: Centre for Rehabilitation of Paralysed, Dhaka, Bangladesh. Methods A descriptive correlational design with modified semi-structured questionnaire implemented through convenient sampling procedure. McDonald’s standard of learning outcome measured criteria was used to categorize caregivers’ level of knowledge and practice while, the total scores of attitude were categorized into three levels based on mean percentage and standard deviation: negative attitude below (mean ± 1 SD), neutral level (mean ± 1 SD), and positive attitude above (mean ± 1 SD). The pearson product-moment correlation coefficient (r) was used to examine the relationships between caregivers’ KAP and p- value of 0.05 or less was considered as statistically significant. Results Our results suggest that caregivers had a moderate level of knowledge (M = 73.68%, SD = 6.43), neutral level of attitude (M = 70.32%, SD = 6.89), and moderate level of practice (M = 74.77%, SD = 9.08). There was a positive correlation between caregivers’ knowledge and attitude (r = 0.30, p < 0.01), and between knowledge and practice (r = 0.37, p < 0.01). However, no correlation existed between attitude and practice (r = 0.12, p > 0.05). Conclusion The study findings suggests that caregivers need to develop a positive attitude and increase their knowledge in order to improve their practice.