This study was performed to examine the association of 2 functional polymorphisms of the promoter region of the serotonin 5-HTR2C receptor gene: -759C/T (rs3813929) and -97G/C (rs518147) with risperidone-induced insulin resistance syndrome in an Indian population. In this case-control study, 52 adult patients of either sex, having no insulin resistance syndrome before initiating treatment, who were previously drug naive and who received risperidone monotherapy for ≥1 year, were recruited in 2 arms. Of them, 26 had risperidone-induced insulin resistance syndrome, and 26 did not have risperidone-induced insulin resistance syndrome. Polymerase chain reaction and DNA sequencing were performed. Multiple logistic regression analysis was performed, and adjusted odds ratio (AOR) was calculated. The polymorphisms did not deviate from Hardy-Weinberg equilibrium (P > .05). For both rs3813929 and rs518147, the variant (AOR 3.95, 95% CI 0.86-21.9 and AOR 4.12, 95% CI 0.88-23.23, respectively) and the heterozygous (AOR 5.21, 95% CI 0.7-61.38 and AOR 4.26, 95% CI 0.76-31.22, respectively) alleles were associated with risperidone-induced insulin resistance syndrome. The other factors associated with risperidone-induced insulin resistance syndrome were male sex, history of risk factors (ischemic heart disease, diabetes mellitus, or stroke) in family, risperidone dose, pretreatment mean arterial blood pressure, fasting blood glucose, and triglycerides. This is the first study conducted in an Indian population to demonstrate that the 2 functional polymorphisms in the 5-HTR2C gene (rs3813929 and rs518147) are associated with risperidone-induced insulin resistance syndrome.

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Introduction: Use of medicinal herbs in the form of food is a famous Ayurvedic art of life prescribed before traditions. Vateria indica Linn. (Sarja) seed butter (Indian tallow) forms a source of edible oil in the household of Udupi and Dakshina kannada Districts of Karnataka. Research and addition of therapeutically useful species enables to preserve the local wealth of tradition and also enriches the existing pharmacopeia. Hence an experimental study was planned to evaluate anti hyperlipidemic activity of V. indica seed butter in albino rats against high fat diet induced hyperlipidemia in Wistar albino rats. Methodology: The 40 animals were divided into five different groups consisting of six rats each. The first normal control group maintained with normal rat diet and water ad libitum. The second positive control group was administered with hyperlipidemic diet (40% cholesterol suspended in hydrogenated vegetable oil, 0.5 ml/100g). The third standard group was administered with Atorvastatin (10mg/kg po). The fourth and fifth trial groups were administered with V. indica seed butter single and double dose (0.43 & 0.86 ml/kg body weight) respectively. Results: The test drug exhibited marginal, moderate increase in HDL cholesterol, moderate decrease in LDL cholesterol, marked reduction in triglycerides with nephroprotective activity. Conclusion: Vateria indica seed butter produced significant antihyperlipidemic activity through normalizing the serum lipid profile. Cytoprotective action has also been revealed by the histopathological examination of liver, heart and kidney tissue.