Introduction: Dengue is a major international health concern that is prevalent in tropical and sub tropical countries. Study of dengue infection and its Liver complications are scarce from countries like India. This study was done to assess the frequency and spectrum of liver dysfunction in Dengue infection patients. Patients and Methods:A hospital based record analysis study was performed at a tertiary care centre. All the inpatients (>18 years) who were diagnosed with dengue infection between January 2015 to May 2017 were included in this study. A total of 281 patients were included in the study. Results:Patients were classified as classical dengue fever (DF) 88.3% dengue haemorrhagic fever (DHF) 7.5% and dengue shock syndrome (DSS) 4.3%. The mean age was 43.13 (+15.50) years and male: female ratio was 2:1. Deranged serum glutamic-oxaloacetic transaminase (SGOT) and/or Serum glutamic pyruvic transaminase (SGPT) was present in 98.9 % of patients .The mean Total Bilirubin, SGOT, SGPT, albumin, ALP (alkaline phosphatase) and INR (International Normalized Ratio) values were 0.95 mg/dl, 687.28 U/L, 293.65U/L, 3.71 g/dl, 112.14 U/L and 1.30 respectively. The mean value of SGOT was significantly higher than SGPT. The degree of rise of SGOT, SGPT, INR, Bilirubin and ALP was significantly more in DHF and DSS, as compared to DF. 28 patients (10%) had evidence of coagulopathy (INR >1.5) and 6 patients had evidence of hepatic encephalopathy. Conclusion:Liver dysfunction in the form of raised SGOT/SGPT was seen in almost all patients with rise in SGOT significantly more than SGPT. Preferentially high SGOT may serve as an early indicator of dengue infection while high values of bilirubin, SGOT, SGPT, ALP and INR may be an indicator of severe disease and poor prognosis.

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Both dual and triple therapy regimes resulted in SVR rates of >95% in CHC genotype 3 who were naive non-cirrhotics. However, the SVR rates were low in treatment-experienced cirrhotics.

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