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BACKGROUNDFrequent haemodialysis is required for the patients with End-Stage Renal Disease (ESRD) to maintain non-toxic levels of serum urea and creatinine. During haemodialysis, increase in 24-hour ambulatory systolic blood pressure (SBP), diastolic blood pressure and blood pressure (BP) load was observed by researchers and that has been explained as high sodium concentration in dialysis solution. Post-dialysis increase in serum alkaline phosphatase level has been reported and this is associated with higher risk of hospitalisation and death. AIMS AND OBJECTIVESSince very little information is available from study on Indian population, our aim was to determine pre and post-dialysis serum alkaline phosphatase and sodium concentrations in subjects of ESRD attending Medicine department of the hospital for haemodialysis at regular intervals with an object to compare our results with available reports from different sources. MATERIALS AND METHODSThe study was conducted in a tertiary care teaching hospital in eastern India by selecting 33 patients suffering from ESRD and they attended the dialysis unit of the hospital for undergoing haemodialysis. Serum sodium, potassium, urea, creatinine and alkaline phosphatase levels were measured. RESULTSPost-dialysis serum urea and creatinine values were lower than pre-dialysis result (p value < 0.001 and < 0.001 respectively). Significant decrease was observed in post-dialysis serum potassium level (p value < 0.001). Increase in serum sodium and alkaline phosphatase levels were observed in post-dialysis subjects (p value < 0.004 and < 0.001 respectively). CONCLUSIONIn the study, we observed a significant increase in serum sodium and alkaline phosphatase concentrations in patients of ESRD after haemodialysis.

BACKGROUNDPre-eclampsia is a complex multisystem disorder that occurs during pregnancy as a complication. This is associated with hypertension and the blood pressure is either 140/90 mmHg or more and in addition proteinuria. Incidence of pre-eclampsia occurs between 3% and 10% of pregnancies and the pathogenic characteristics are vasospasm, increased peripheral vascular resistance and reduced organ perfusion. Exact cause of pre-eclampsia is still unexplored, but improper placentation is an important factor, and among other causes generation of free radicals leading to oxidative stress is thought to be the prime cause.Oxidative stress results in damage to the biomolecules with generation of reactive oxygen species, and since the lipid peroxidation products play major roles in generation of free radicals our objective was to establish a correlation between lipid profile and an important lipid peroxidation intermediate like malondialdehyde in maternal and cord blood of women with preeclampsia.

Background: To find out the prevalence of vitamin D deficiency in patients hospitalised in two tertiary care centres for various ailments in Eastern Bihar and North Bengal. Methods: Hospitalised patients in MGM Medical College, Kishanganj, Bihar and Medical North Bengal Clinic, Siliguri, West Bengal (Jan 2014 to Dec 2014) who underwent blood sampling for vitamin D estimation in their work up for various ailments were included in the study. Result: Out of 108 patients, 65 were female and 43 were male in the age group ranging from 1 month to 85 years. Maximum number of patients was in the age group of 41 to 60 years. Seventy two percent patients had low vitamin D levels with 54.63% having frank deficiency and 17.59% had insufficient levels. Diabetes mellitus and/or hypertension were the most common diseases associated with hypovitaminosis D followed by diseases of respiratory system. Conclusion: Vitamin D deficiency was seen in 72 % of the subjects with female preponderance. No age was spared as the age of the subjects ranged from 1 month to 85 years with majority in the 41 to 60 years age group. Among subjects with hypovitaminosis D, diabetes mellitus and /or hypertension were the most commonly encountered diseases.

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