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Metal-organic frameworks (MOFs) are not much investigated as catalysts in copolymer formation with cyclic esters. Herein, we report the ring-opening copolymerization of -caprolactone (CL) with δ-valerolactone (VL) using a recoverable...

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Sexual dysfunction is a common, underappreciated complication of diabetes. Male sexual dysfunction among diabetic patients can include disorders of libido, ejaculatory problems, and erectile dysfunction (ED). All three forms of male dysfunction can cause significant bother for diabetic patients and can affect their quality of life. Diabetic patients take oral hypoglycemic drug to control their diabetic as well as take herbal sex stimulants to control to increase the libido. The combined use of herbs and drugs has increased the possibility of herb-drug interactions. The study was undertaken to explore the herb-drug interactions. To investigate the herbdrug interactions an in vitro dissolution study in different simulated pH medium were performed. In this study gliclazide containing tablet of 80mg as oral hypoglycemic drug and different herbal sex stimulants available in local market were used. The release mechanism was explored and explained with zero order, first order and Higuchi equations to identify drug interaction. Higher percentage release of gliclazide was found at simulated phosphate buffer of pH 7.4 compared to gastric medium of pH 1.2 and also in presence of herbal sex stimulants. Increased release pattern of gliclazide

Background Rheumatoid arthritis (RA), an autoimmune disorder, characterized by systemic inflammation and swollen joints, establishes itself as a critical threat. A pro-inflammatory cytokine TNF-α is a well-known driver of RA pathogenesis and at the same time predisposes to insulin resistance through signal impediment which ultimately paves the way for type 2 diabetes (T2DM). However, in patients with RA, T2DM remains significantly undiagnosed or undertreated, apparently which increases the risk of developing cardio-metabolic comorbidities. This study aimed to evaluate the glycemic status among RA patients and its association with disease activity. Result One hundred fifty inpatients RA cases according to ACR/EULAR standards were included in the cross-sectional study who have an average age of 45.4±12.15 years and a median and interquartile period of RA of 2.25 years and 0.48–6 years, respectively. We discovered that 36% of people had T2DM, 26% were prediabetic, and 38% were non-diabetic. Age was shown to be significantly correlated with DM frequency in RA patients (p=0.007). There were 28 patients with elevated disease activity (19%) and 60 patients with low disease activity (40%) in this study. No substantial associations were found in the presence of DM with gender, anti-CCP, RF, disease duration, or DAS28. Conclusion RA patients are more likely to experience diabetes, and resultantly a high index of notion must be kept. Clinician should be aware about the affliction of undiagnosed diabetes and prediabetes in RA patients. Furthermore, keeping an eye on glycemic control in RA patients could prevent metabolic and cardiovascular comorbidities in those susceptible patients.