Narendra et al.: Phenylvilangin-Synthesis and Biological activitiesPlants contain a wide variety of secondary metabolites that are used either as drugs or lead compounds in the synthesis of interesting chemicals that show promise in drug discovery. Quinones and their derivatives are one such group of specialized compounds that exhibit amazing biological properties. In this study, a benzoquinone derivative phenylvilangin has been synthesized from the naturally occurring embelin and its structure was confirmed by Infrared Spectroscopy, Proton Nuclear Magnetic Resonance, Carbon-13 nuclear magnetic resonance, Distortionless enhancement by polarization transfer and mass spectral analysis. Phenylvilangin has been screened for free radical scavenging and cytotoxic by in vitro methods wherein it exhibited significant activities suggesting that it could be a compatible material for further investigation to develop as a potential drug candidate. On comparison of the above bifunctional activities of phenylvilangin with those of the parent quinone embelin and another derivative vilangin, it has been found that phenylvilangin possessed better potential than the other two compounds.

Dental avulsion is considered as one of the most severe types of traumatic tooth injuries because it causes damage to several structures and results in the complete displacement of the tooth from its socket in the alveolar bone. The ideal situation is to replant the tooth immediately after avulsion because the extra oral time is an important determinant for the success of the treatment and for a good prognosis. The aim of this systematic review was to identify the recommended natural storage m to store and transport avulsed tooth based on the survival capacity of periodontal ligament cells.This paper reviews the different storage media that have been evaluated for avulsed teeth based on full-length research papers retrieved from PubMed/Medline, Lilacs, BBO and SciELO electronic databases using the key words 'storage medium', 'avulsion', 'tooth avulsion', 'replantation', 'tooth replantation', 'milk' and 'propolis'.Based on the application of inclusion and exclusion criteria, about 14 papers have been selected and critically reviewed with respect to the characteristics, efficacy and ease of access of the storage media. The review of this study shows and includes a wide array of wet storage media that have been evaluated in laboratory-based studies on PDL cells found on adult permanent teeth.Among the natural products other than milk, propolis, coconut water, green tea extract, egg white, green tea extract, Alovera gel, pomegranate juice, salvia officinalis followed by dragon blood sap (Croton Lechleri) were recommended based on the cell viability and its longevity. In an emergency, it is important for dentists to consider the circumstances of the accident, the location and suggest an appropriate transport media.

Background: Endodontics has always been indebted to pharmaceutical sciences to provide it with necessary analgesics and anti-inflammatory agents. More specifically, there has always been a need for anti-inflammatory phytotherapeutic agents as the commercially available synthetic anti inflammatory drugs have their own limitations due to undesirable side effects. Hence, novel potent analgesic and anti-inflammatory drugs without considerable side effects from the natural sources are under evaluation. Tecoma stans (Bignoniaceae) is an ornamental plant found throughout India. It has been shown to have variety of medicinal properties. In the present study, we have shown that potential anti inflammatory activity of different parts of Tecoma stans (T.stants) and compared with standard drug. Aim: To evaluate the in vitro anti inflammatory potential of different parts of T.stans ethanolic extract and to compare the anti inflammatory activity with standard drug ibuprofen. Methodology: The ethanolic extraction of T.stans's bark, leaves and floweres was done as per the standard method. Different concentrations (100, 200, 300, 400 and 500 µg/ml) of the extracts were used for anti-inflammatory activity by inhibition of albumin denaturation. All samples were analyzed in triplicate. The results were statistically analyzed. Results: All the three parts of the plant extract have shown to have anti inflammatory activity in a dose-dependent manner. However, the leaf and flower extracts of T.stans were found to have 100 percent anti-inflammatory pontential than standard drug ibuprofen. Conclusion: It is concluded from the present findings that T.stants possess anti-inflammatory properties which could be due to presence of active constitutents presen in the plant extracts. Hence, T.stans may serve as one of the anti inflammatory herbal durgs for Endontic infection-induced inflammation and related to dental diseases. Further studies on the identification of the active principles present in the leaf and flower extract are warranted to assertatin its potentials.

No abstract

The modern era is seeing an incline in dental health issues namely dental caries, missing teeth, etc. causing an increased use of prosthetics to replace the function of such teeth or provide esthetics. This has led to various studies in this field to improve the quality and lifespan of the crowns. An important aspect of this is to consider the cementation process and luting material used, which are crucial in determining the result. A retrospective study was done on patients reporting to Saveetha Dental College and Hospitals. A sample size of 1055 was obtained and data tabulated using the Excel sheet. SPSS software was used to analyze the data statistically. Chi-square test was done to evaluate the association between tooth type and cement used, USPHS scores for adaptation, colour match, marginal discoloration and surface roughness. The study revealed that GIC was the most common luting material used which was statistically significant and lower molars were the most involved sites for cementation. The most common USPHS score for adaptation, marginal discoloration and surface roughness for all types of tooth was Score 0. For color match, the most common USPHS score was Score 1.