This review examines changes in the hemostatic system parameters in patients with COVID-19 and analyzes their practical significance. The article discusses modern approaches to the prevention and treatment of thrombotic/thromboembolic complications in COVID-19.
For the first time on the Fergana Valley model, prognostic markers of the risk of thrombotic complications in COVID-19 patients with type 2 diabetes were studied. It was found that the level of glycemia, the concentration of proinflammatory cytokines IL-6, ferritin and CRP, and the marker of thrombus formation - d dimer, have a prognostic significance, with the maximum prognostic significance of the concentration of CRP. The prognostic significance of ultrasound in the aspect of thrombosis of the branches of the PA in patients with COVID-19 against the background of type 2 diabetes was established. Predictor markers are mean PA pressure, LV myocardial mass index, signs of increased intraventricular pressure in the RV, and evidence of peripheral venous thrombosis.
The Fergana Valley model was used to study the risk of postcovid interstitial lung disease in patients who have had COVID-19 associated pneumonia with 50% or more of the pulmonary parenchyma affected. Predictors of the formation of postcovid pulmonary fibrosis were determined and a risk assessment scale was developed. It was found that the use of ultrasound scanners in the early postcovid period is informative and is not inferior in terms of predicting fibrosis by serial MSCT.
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