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We propose the use of branched gold nanoparticles (B-GNPs) as a contrast agent for optical coherence tomography (OCT) imaging. Our results show that even when the central source of our OCT (1325 nm) is too far from the maximum peak of the plasmon resonance, branched nanoparticles scatter light very efficiently at this wavelength. B-GNPs were tested as a contrast agent in water and agarose-TiO 2 tissue phantoms; the estimated increments in contrast were 9.19 dB and 15.07 dB for branched nanoparticles in water with concentrations of 2.2 × 10 9 NPs/mL and 6.6 × 10 9 NPs/mL, respectively, while for agarose-TiO 2 tissue phantoms the estimated value was 3.17 dB. These results show the promising application of B-GNPs as a contrast agent for tissue imaging using OCT, not only for sources at 1325 nm but also at other central wavelengths located between 800 and 1000 nm.

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