Sepsis adalah keadaan disfungsi organ yang mengancam jiwa yang disebabkan karena disregulasi respon tubuh terhadap infeksi. Sepsis juga merupakan penyebab kematian utama di antara pasien kritis unit perawatan intensif non-koroner di Amerika Serikat. Tahun 2010 tercatat prevalensi pasien rawat intensif yang menderita sepsis di Rumah Sakit Dr.Cipto Mangunkusumo adalah 25% dengan derajat mortalitas sebesar 77,3%. Untuk menilai seberapa berat respons inflamasi digunakan biomarker. Salah satu biomarker yang digunakan adalah neutrophil- lymphocyte ratio (NLR). Sampai saat ini masih belum digelar konsensus untuk melihat hubungan antara NLR dengan prognosis pasien sepsis. Melihat hubungan neutrophil-lymphocyte ratio terhadap mortalitas pasien sepsis di ICU RSUP Haji Adam Malik.Penelitian ini merupakan penelitian analitik dengan desain penelitian berupa cross-sectional. Data penelitian ini menggunakan data sekunder berupa rekam medis dan metode pengumpulan data berupa total sampling. Dari hasil penelitian, didapatkan insidensi sepsis di Intensive Care Unit (ICU) Rumah Sakit Umum Pusat (RSUP) Haji Adam Malik sebanyak 97 pasien dan didominasi oleh pasien lansia dan laki-laki dengan jumlah pasien masing-masing sebesar 58 orang. Analisis bivariat menggunakan uji Fisher’s Exact Test didapatkan tidak adanya hubungan yang signifikan secara statistik dengan nilai p value 0,371 antara NLR terhadap mortalitas pasien sepsis. Tidak didapatkan hubungan neutrophil- lymphocyte ratio terhadap mortalitas pasien sepsis.

Background. Pediatric Acute Respiratory Distress Syndrome (PARDS) is considered to occur due to direct lung injury and indirect lung injury. The research aims to describe the causes of PARDS in patients treated at the Pediatric Intensive Care Unit (PICU) of Haji Adam Malik Hospital Medan in 2017-2020. Method. This type of research is a retrospective descriptive study with a cross-sectional study design uses secondary data in the form of medical records. The population of this study were all PICU patients aged 1 month – 18 years at Haji Adam Malik Hospital Medan in 2017-2020 using consecutive sampling technique. Results. Of the 100 PICU patients, there were 55 male patients with the most age group was <12 months. The most common mode of ventilation used is 80 invasive mechanical ventilation and duration of ventilation used has a mean value of 17.72 days. A mean value of Length of stay (LOS) patient was 25.47 days. Based on the Oxygenation Index (OI), of the 80 patients with invasive mechanical ventilation, most patients were 57 at risk PARDS, meanwhile, based on Oxygen Saturation Index (OSI) categories, of the 20 patients with non-invasive mechanical ventilation, most patients were 15 at risk PARDS. Most caused by indirect lung injury, namely 51 (51%), direct lung injury 47 (47%), and due to complications of using a ventilator as much as 2 (2%). Conclusion. The most common direct lung injury factor is the primary pulmonary infection, aspiration, trauma, and other factors. The most common indirect lung injury factor is sepsis, then central nervous system (CNS) disorders, postoperatively, and other factors.