Background: Current treatment for CSOM is still unsatisfactory, many factors contributed in this condition. Impaired mucociliary clearance of the Eustachian tube can be a predisposing factor for recurrent otitis media and slow healing of the middle ear mucosa, local circulation and improvement of middle ear pressure. During process of middle ear infection, mucus production commonly found, the middle ear and the Eustachian tube are disturbed. The erdosteine effects of increase epithelial mucociliary transport are well documented. Objectives: To investigate the effectiveness erdosteine in mucociliary transport of benign CSOM. Method: sixteen (16) patients with benign CSOM were experimental research, using pretest-posttest control group design method with random sampling. The two main comparisons were transport mucocilary time compared to a) erdostein and b) no erdostein. Result: The study analyzed the interval time of mucociliary transport between pretest and posttest was measured in studied patients. The transition time from pretest to posttest with erdosteine from 24:36:22 to 16:28:32 minutes (p=0,006) and without erdostein from 22:12:39 to 19:18:19 minutes (p=0,029). There is a difference in transportation time before and after administration of erdostein. However, there were no significant difference in mucociliary transport time from pretest to posttest between 2 groups (p=0.682). Conclusions: The results of our study indicate that erdosteine is correlated with increased mucociliary transport. Eventhough the interval time have no significance different between erdorsteine group and without erdorsteine group.