Chronic kidney disease is characterized by structural abnormalities or progressive or permanent loss of renal function for three months or more and is often accompanied by a glomerular filtration rate of less than 60 mL/min/1.73 m2. The objective of the study is to assess the risk factors contributing to chronic kidney disease among the patients between cases and controls in the Medical City Complex and to predict variables that contribute to the risk factors of chronic kidney disease among the studied samples. The study, a case-control design, has been carried out in Baghdad's Medical City Complex. Information was gathered for a full five months, included in the sample of 300 (150 cases and 150 controls). The result was The likelihood of developing chronic kidney disease was highly correlated with a history of hypertension, acute kidney disease, renal stones, and anemia. Also, both open kidney surgery and extracorporeal shock wave lithotripsy decrease kidney function and make it more likely that you will get chronic kidney disease.