Objectives: The aim of study is to evaluate plasma glucose control in diabetic patient on hemodialysis by measure plasma glycated albumin and HbA1c and correlate them with parameters like serum electrolytes blood urea, serum creatinine, hemoglobin, serum albumin, total serum bilirubin, serum uric acid, parathyroid hormone, serum ferritin; to evaluate the effects of these parameters on the level of diabetic control. Methods: This is a cross sectional study which included type 2 diabetic patients on hemodialysis these patients are currently undergoing hemodialysis and are on hemodialysis for more than three months. Total 50 type 2 diabetic patients on hemodialysis; between ages of 47-62 years of either gender were selected randomly and comparison done between the effect of different factors on HbA1c and glycated albumin. Results: There were 50 patients enrolled in this study with a mean age of 54.5 ± 4.7 (range: 47 – 62) years. Males represented 58% (29 patients) while female represent 42% (21 patients) of the studied group with male to female ratio of 1.38 to one. The duration of diabetes (DM) ranged 4 – 20 years and two thirds of the cases had duration of 15 years or less. Regarding the treatment of DM, 35 patients (70%) were on soluble insulin while 15 patients neither receive insulin nor oral antidiabetic agent and their treatment was off. poor glycemic control was significantly associated with younger age, patients aged < 50 years were more frequent among the poor glycemic. good glycemic control had significantly lower HbA1C% level. Conclusion: Most of our diabetic patient on HD has controlled diabetes reflected by the level of HbA1c and GA. Serum ferritin levels is positively correlate with HbA1c levels in diabetic patient on hemodialysis which suggests that serum ferritin levels can be a marker of glycemic control in type 2 DM.
Background: Diabetic nephropathy (DN) is one of the most well-known diabetic microvascular complications, affecting around 40% of individuals with type 2 diabetes mellitus (T2DM). It progresses to end-stage renal disease (ESRD), and its primary detection can be done via diabetes biomarkers. The power of early biomarker identification of DN in T2DM serum is evaluated in this study. Aim: This study aimed to assess the possibility of using ΒTP and Cys. C as earlier markers for the detection of nephropathy in patients with type 2 DM. Materials and Methods: This is a cross-sectional study. It included one hundred twenty patients with T2DM, composed of 66 males and 45 females, and aged 40–69 years, who were divided into 3 groups by using the urinary albumin/creatinine ratio (ACR): Group I: (N = 40 Normoalbuminuria UACR < 30 mg/g as control), Group II: (N = 40 Microalbuminuria UACR 30–300 mg/g), Group III: (N = 40 Macroalbuminuria UACR ˃ 300 mg/g). In all groups, βTP and Cys. C were estimated in the serum of patients, and both biomarkers had the same methodology by quantitative enzyme immunoassay (double-antibody sandwich).
Chronic kidney disease is characterized by structural abnormalities or progressive or permanent loss of renal function for three months or more and is often accompanied by a glomerular filtration rate of less than 60 mL/min/1.73 m2. The objective of the study is to assess the risk factors contributing to chronic kidney disease among the patients between cases and controls in the Medical City Complex and to predict variables that contribute to the risk factors of chronic kidney disease among the studied samples. The study, a case-control design, has been carried out in Baghdad's Medical City Complex. Information was gathered for a full five months, included in the sample of 300 (150 cases and 150 controls). The result was The likelihood of developing chronic kidney disease was highly correlated with a history of hypertension, acute kidney disease, renal stones, and anemia. Also, both open kidney surgery and extracorporeal shock wave lithotripsy decrease kidney function and make it more likely that you will get chronic kidney disease.
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