The present study aimed to explain the effect of Bay leaf and its isolated flavonoids and glycosides on the levels of TC, TG, HDL-C, LDL-C and VLDL-C in the local Iraqi female rabbits. Isolation of flavonoids and glycosides from Bay leaf were carried out, the study design included four groups (n=6): Control group-C fed with standard pellet diet; group1-G1 orally administrated daily dose 100 mg/ml/kg of Bay leaf crude for 30 days; group2-G2 orally administrated daily dose 50 mg/ml/kg of isolated flavonoids for 30 days; group3-G3 orally administrated daily dose 12.5 mg/ml/kg of isolated glycosides for 30 days. TC, TG and HDL-C were determined by enzymatic colorimetric method. The results showed that oral administration of Bay leaf and its isolated flavonoids and glycosides reduced levels of TC, TG, LDL-C and VLDL-C compared to control, therefore Bay leaf useful agent in reducing hyperlipidemia.
A study was conducted on 64 serum samples of blood from people [36 male and 28 female] aged between 48-65 years old, 47 of whom suffer from chronic high blood pressure, and divided the patient samples to the first group using the drug Tenordin, and a second set using drug Captosam, and 17 healthy sample 9 male and 8 Female control group for comparison.
The results showed a significant increase in the activity of the alkaline phosphatase ALP for the first group, 19.44±2.94 Kind and King/100ml compared with control group 14.24±2.14 Kind and King/100ml. The second group showed a significant decrease enzyme activity, amounting to 7.16 ± 1.90 Kind and King/100ml compared with the control group.
Three different concentrations of drugs Captosam and Tenordin were prepared and studied their impact on the effectiveness of the enzyme ALP in vitro, and results showed that the drug Tenordin shows a strong activating effect, but the drug Captosam showed remarkable inhibition effect. Also studied the kinetics of the effect of a drug Captosam inhibitor on the activity of the enzyme and the results showed that the value of Km is 6.8965 mmol /L, while the value of Vmax are 12.5 mmol /L min., as results showed when studying the inhibition of the low values of Km and Vmax, as the value of Km is 3.077 mmol /L, while the Vmax value was 5.555 mmol /L min., and shows that the inhibition type is Uncompetitive.
The present study deals with the phytochemical, nutritional, mineral contents and in vitro antioxidant activity of Commiphora myrrha. Preliminary phytochemical result indicate that the plant contain phenolic compounds, flavonoids, tannins, glycosides, alkaloids, terpenoids and quinines. Secondary Metabolites has been estimate quantitatively, the highest concentration of tannins 3677.1 ±2.15 mg/100g and then for alkaloids 1880 mg/100g, sterols 155.215 ±1.00 mg/100g, and Flavonoids 47.266 ±0.013 mg/100g and phenolic compounds 30.647 ±2.481 mg/100g. Nutritional Profiling, minerals and antioxidant activity were determined. Flavonoids and glycosides isolated were exhibited lower reducing power and scavenging ability than ascorbic acid
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