Political evolution is the ultimate objective of all political systems. Political development is the enemy of progress in several domains, as well as the syndrome of difference, equality, and mass ability creation. There is a substantial positive association between a country's national and socioeconomic circumstances and its political growth. This includes the GDP growth rate and the urbanization rate, mass mobilization and engagement, educational growth, and democratic principles. Since its birth, Pakistan has been on a path of political growth and has seen several social transformations and a modernization drive in its society. Pakistan has reached a modest rate of growth, and its society is in a transitional phase between a traditional agricultural civilization and an industrialized one. Although the development process is gradual, it is rather stable with few setbacks. The rapid expansion of information technology and increased communication platforms have ushered in new developments and modernization movements in society. In this paper, we will explore if there is any correlation between political development and social conditions in Pakistan.

Non-bullous congenital ichthyosiform erythroderma (NCIE) is characterized by skin scaling with erythema. In this study, two Pakistani families with NCIE are genetically characterized through Whole Exome and Sanger sequencing to identify molecular basis of the disease. We identified a nonsense homozygous c.2026C>T mutation of ALOXE3, causing premature termination of the eLOX3 protein (p.Q676X). In silico studies predicted impaired enzymatic activity of the premature truncated eLOX3, leading to abnormal synthesis of specific hepoxilin derivatives, essential for epidermal barrier formation. It is the first ever study reporting homozygotes of p.Q676X mutation in ethnically distinct two Pakistani families; otherwise, heterozygotes of the said mutation have been reported in South Asian population only. Hence, mutation seems to be region-specific and may be useful for molecular diagnosis of NCIE. Moreover, our findings should help in genetic counseling and career screening.