Conclusion:In this cohort of infants, ARI incidence was 1.8 episodes per year per infant; 95% were URTIs. Viruses were identified in 63.3% episodes and the common viruses detected were RV, RSV and parainfluenza virus.
.
Mauriac syndrome is a rare and underdiagnosed complication of type 1 diabetes mellitus
(T1DM). It is characterized by growth retardation, delayed puberty, Cushingoid features,
hepatomegaly, and increased transaminase levels. The term glycogenic hepatopathy has been
used to describe patients with poorly controlled T1DM and glycogen overload in the
hepatocytes but without all the features of Mauriac syndrome. Although rare, glycogenic
hepatopathy is reported to be the main cause of hepatomegaly in young patients with T1DM.
We report two cases of glycogenic hepatopathy in children with poorly controlled T1DM.
Both children had hepatomegaly, elevated liver enzyme levels, and elevated lactate levels.
A liver biopsy confirmed the diagnosis of glycogenic hepatopathy in both patients. In
conclusion, hepatomegaly with elevated liver enzymes, negative infective and metabolic
screenings and persistently elevated plasma lactate levels should raise the suspicion of
glycogenic hepatopathy in poorly controlled T1DM. Early diagnosis and improvement in
glycemic control are the mainstays of treatment, which can prevent long-term
complications.
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