Insights into the dynamics of endemic Coxiella burnetii infection in cattle by application of phase-specific ELISAs in an infected dairy herd. Veterinary Microbiology, Elsevier, 2011, 151 (3-4) This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.Page 1 are available, they are not yet used in ruminants as they are in humans. This study focuses on 14 phase-specific serology as a tool for analysis of the dynamics of infection in cattle. As a 15 prerequisite, sero-prevalence in Bavarian cattle (1) and sero-prevalences for age-groups (2) were 16 determined by ELISA (CHEKIT Q-Fever; mix of PhI/PhII-antigen). Subsequently, phase-17 specific antigens were coated onto ELISA plates individually and tests were simultaneously 18 applied in an endemically infected herd with about 90 dairy cows and 250 calves/heifers

To satisfy the intra- and inter-system bandwidth requirements of future data centers and high-performance computers, low-cost low-power high-throughput optical interconnects will become a key enabling technology. To tightly integrate optics with the computing hardware, particularly in the context of CMOS-compatible silicon photonics, optical printed circuit boards using polymer waveguides are considered as a formidable platform. IBM Research has already demonstrated the essential silicon photonics and interconnection building blocks. A remaining challenge is electro-optical packaging, i.e., the connection of the silicon photonics chips with the system. In this paper, we present a new single-mode polymer waveguide technology and a scalable method for building the optical interface between silicon photonics chips and single-mode polymer waveguides.

We report on the implementation of novel flexible polymer waveguide interconnects. They are based on newly developed mechanically flexible low-loss silicone waveguides. In addition to meeting the generic requirements of rigid waveguide interconnects, several flex-material challenges were mastered: a) mechanical flexibility permitting waveguide flexing down to radii of 1.0 mm without cracking; b) minimization of waveguide curling induced by the CTE mismatch between flex substrates and polymer layers to enable assembly and connectorization; c) greatly improved cladding adhesion on standard PCB flex substrates, such as polyimide; and d) high environmental stability despite the reduced polymer cross-linking required for better mechanical flexibility. The new waveguides exhibit excellent stability in damp heat (2000 h in 85 • C/85% rH) and under thermal shock (500 cycles from -40 • to +120 • C), and lead-free solder reflow up to 260 • C. Using the newly engineered "Dow Corning WG-1017 Optical Waveguide Clad Dev Sample" and the established "Dow Corning WG-1010 Optical Waveguide Core", we were able to develop a manufacturing process suitable for large areas and offering high process control and stability to produce waveguides having optical loss values of less than 0.05 dB/cm at 850 nm VCSEL wavelength and fulfilling requirements (a) to (d) above. We describe this manufacturing process and how we have overcome the material challenges mentioned. Furthermore, we present characterization and manufacturing results, show demonstrators, and outline the potential of flexible waveguides as versatile electro-optic assembly platform.

This study demonstrates enhancement of in-device electro-optic activity via a series of theory-inspired organic electro-optic (OEO) chromophores based on strong (diarylamino)phenyl electron donating moieties. These chromophores are tuned to minimize...

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