Reduced arterial compliance in patients with diabetes mellitus has been shown in several studies, but it has not been significantly associated with either atherosclerosis or vessel wall thickness. Blood pressure variability is still poorly explored in diabetic patients. The aim of this study was to compare blood pressure variability and arterial compliance in patients with type 2 diabetes mellitus and controls matched for sex, age, and weight. Arterial compliance was measured and noninvasive 24-h ambulatory blood pressure monitoring was performed in 18 diabetic patients and 18 controls. There was significantly higher 24-h systolic blood pressure variability (17.7 +/- 6.8 vs. 14.6 +/- 2.6 mm Hg), diastolic blood pressure variability (15.6 +/- 7.1 vs. 11.4 +/- 3.1 mm Hg), and mean arterial blood pressure variability (14.8 +/- 7.0 vs. 11.1 +/- 2.9) in diabetic patients. Systolic, diastolic, and mean arterial blood pressure variability was significantly higher during daytime but not night time in diabetic patients compared to controls. Diabetic patients also had significantly reduced small artery compliance, but no differences in large artery compliance, cardiac output, or systemic vascular resistance. The findings suggest that hyperglycemia may affect the compliance of the vascular system, resulting in high blood pressure fluctuations.

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on behalf of the ANBP2 Echo Study Committee .Background: Hypertension leads to cardiac structural and functional changes, commonly assessed by echocardiography. It is not clear which echocardiographic parameters are most predictive of future cardiovascular events among elderly treated hypertensive patients over short or long term.Objectives: To assess the predictive performance of echocardiographic findings for having cardiovascular outcomes in elderly hypertensive patients. Methods:We used echocardiographic data from the LVH sub-study of the Second Australian National Blood Pressure trial. Participants aged ≥65-yrs were followed for a median of 4.1 years (short-term) and an additional median 6.9 years (longterm) for any cardiovascular events. Echocardiograms were performed at baseline to estimate left ventricular hypertrophy (LVH), LV systolic and diastolic dysfunction, LV wall thickness and relative wall thickness. LV mass was calculated according to the American Society of Echocardiography criteria and LVH was defined based on LV mass indexed according to body surface area (male >115 g/m 2 , female >95 g/m 2 ). Cox-regression proportional hazard models were used to understand the relationship between echocardiographic findings and cardiovascular events. 4 105.0±8.3 157.6±10.6 109.4±8.1 α 119.7±9.7 α 123.9±14.5 α 138.3±9.2 Data are expressed as mean ± SD. NC: normal control, L-NAME: L-name only,CAP: L-name + captopril (100mg/kg/day), TQ10: L-name + thymoquinone 10mg/kg, TQ5:L-name+thymoquinone 5mg/kg, TQ2.5:L-name + thymoquinone 2.5mg/kg. α significantly lower compared to L-NAME group at (P< 0.01) using one-way ANOVA followed by Tukey test.

Tujuan Membandingkan reaktivitas kardiovaskular terhadap tes mental dan fi sik antara subjek normotensif dengan riwayat keluarga hipertensi dan subjek normotensif tanpa riwayat keluarga hipertensi. Metode Mahasiswa normotensif dengan (n=40) dan tanpa (n=40) orangtua hipertensi melakukan tes aritmatika dan cold pressor. Kedua tes tersebut terdiri dari fase istirahat pra-tes, fase tes, dan fase istirahat pascates. Parameter kardiovaskular diukur pada tiap fase dengan menggunakan alat pengukur tekanan darah osilometrik otomatis. Data di analisis dengan tes t atau Mann-Whittney. Reaktivitas kardiovaskular diketahui berdasarkan selisih nilai fase tes dengan fase pra-tes. Hasil Kedua kelompok tidak berbeda bemakna dalam usia, indeks masa tubuh, kadar gula darah puasa, dan kadar kreatinin plasma. Subjek normotensif dengan orangtua hipertensi menunjukkan tekanan darah sistolik istirahat