Antihypertensive and Antihyperlipidemic Activities of Thymoquinone in L-Name Hypertensive Rats

Abstract

on behalf of the ANBP2 Echo Study Committee .Background: Hypertension leads to cardiac structural and functional changes, commonly assessed by echocardiography. It is not clear which echocardiographic parameters are most predictive of future cardiovascular events among elderly treated hypertensive patients over short or long term.Objectives: To assess the predictive performance of echocardiographic findings for having cardiovascular outcomes in elderly hypertensive patients. Methods:We used echocardiographic data from the LVH sub-study of the Second Australian National Blood Pressure trial. Participants aged ≥65-yrs were followed for a median of 4.1 years (short-term) and an additional median 6.9 years (longterm) for any cardiovascular events. Echocardiograms were performed at baseline to estimate left ventricular hypertrophy (LVH), LV systolic and diastolic dysfunction, LV wall thickness and relative wall thickness. LV mass was calculated according to the American Society of Echocardiography criteria and LVH was defined based on LV mass indexed according to body surface area (male >115 g/m 2 , female >95 g/m 2 ). Cox-regression proportional hazard models were used to understand the relationship between echocardiographic findings and cardiovascular events. 4 105.0±8.3 157.6±10.6 109.4±8.1 α 119.7±9.7 α 123.9±14.5 α 138.3±9.2 Data are expressed as mean ± SD. NC: normal control, L-NAME: L-name only,CAP: L-name + captopril (100mg/kg/day), TQ10: L-name + thymoquinone 10mg/kg, TQ5:L-name+thymoquinone 5mg/kg, TQ2.5:L-name + thymoquinone 2.5mg/kg. α significantly lower compared to L-NAME group at (P< 0.01) using one-way ANOVA followed by Tukey test.

Occurrence and Bioactivity Diversity of Thymoquinone: An Overview

“…In hyperlipidemic rabbits, TQ exhibited positive effect on aminotransferases, insulin and serum glucose by lowering of reactive oxygen species in steatosis caused by elevated cholesterol diets [92,93]. TQ lowered the elevated blood pressure induced by the 4-week administration of L-nitro-arginine methyl ester to rats via reducing serum aldosterone concentration, implying TQ-action through the renin-angiotensin-aldosterone system [94]. The role of TQ in preventing and/or treating atherosclerosis is combatting hyperlipidemia, oxidative stress, and inflammation in atherosclerosis and preventing foam cell formation by decreasing low-density lipoprotein (LDL) availability and oxidation [95,96].…”

Chemopreventive Efficacy of Thymoquinone in Chemically Induced Urinary Bladder Carcinogenesis in Rat

“…Thymoquinone (TQ) "2-isopropyl-5-methyl-1, 4benzoquinone" is the main active constituent of the Nigella sativa Linn (black cumin) seed oil extract which has been traditionally used in the Middle East and Southeast Asian countries as the blessing seed. It exhibits pleiotropic activity including anti-inflammatory, antihistaminic, antihypertensive, hypoglycemic, immune enhancement, and antiarthritic [3,4]. Furthermore, it has anticancer and antioxidant actions in various types of cancers such as breast, bone, cervix, liver, colon, blood, oral, head and neck, prostate, kidney, and bladder [5][6][7].…”