Gastroprotective is an effect caused by the compounds that have the capability of protecting the gastric mucosa. Peperomia pellucida plants contain alkaloids, avonoids, saponins, tannins, and terpenoids, while Pachyrhizus erosus contains avonoids, alkaloids, tannins, and saponins. Peperomia pellucida reportedly contains dillapiole compounds with a gastroprotective effect. Moreover, its isolation result from Pachyrhizus erosus indicates the presence of dulcitol, gentisic acid, and formononetin, which has antioxidant activity. This study aims to determine the gastroprotective effect of the combination of Peperomia pellucida and Pachyrhizus erosus extract on rats with gastric ulcer models by looking at the ulcer index, percentage of inhibition, and histopathology. The research method used in this study was by making a combination of Peperomia pellucida and Pachyrhizus erosus extract. The combined extract was then given to 5 treatment groups. Group I as a negative control, group II as a positive control was given sucralfate, groups III, IV, and V were given a combination of Peperomia pellucida and Pachyrhizus erosus extract of 100, 200, and 400 mg/kg BW. The treatment was given orally for 14 days, after one hour of treatment on the 14th day, 96% ethanol induction was given orally at a dose of 5 mg/kg BW. The animal dissection was performed 24 hours after the induction. The results from observations showed an increase in body weight before and after the treatment. The ulcer index produced by negative control, positive control in the treatment with doses of 100, 200, and 400 were 4.18; 2.98; 2.42; 2.04; and 1.07. This study showed that the combination of Peperomia pellucida and Pachyrhizus erosus extract has a gastroprotective effect.

Gastroprotective is an effect caused by the compounds that have the capability of protecting the gastric mucosa. Peperomia pellucida plants contain alkaloids, flavonoids, saponins, tannins, and terpenoids, while Pachyrhizus erosus contains flavonoids, alkaloids, tannins, and saponins. Peperomia pellucida reportedly contains dillapiole compounds with a gastroprotective effect. Moreover, its isolation result from Pachyrhizus erosus indicates the presence of dulcitol, gentisic acid, and formononetin, which has antioxidant activity. This study aims to determine the gastroprotective effect of the combination of Peperomia pellucida and Pachyrhizus erosus extract on rats with gastric ulcer models by looking at the ulcer index, percentage of inhibition, and histopathology. The research method used in this study was by making a combination of Peperomia pellucida and Pachyrhizus erosus extract. The combined extract was then given to 5 treatment groups. Group I as a negative control, group II as a positive control was given sucralfate, groups III, IV, and V were given a combination of Peperomia pellucida and Pachyrhizus erosus extract of 100, 200, and 400 mg/kg BW. The treatment was given orally for 14 days, after one hour of treatment on the 14th day, 96% ethanol induction was given orally at a dose of 5 mg/kg BW. The animal dissection was performed 24 hours after the induction. The results from observations showed an increase in body weight before and after the treatment. The ulcer index produced by negative control, positive control in the treatment with doses of 100, 200, and 400 were 4.18; 2.98; 2.42; 2.04; and 1.07. This study showed that the combination of Peperomia pellucida and Pachyrhizus erosus extract has a gastroprotective effect.

Gastroprotective effects are caused by compounds that can protect the gastric mucosa. Gastroprotective activity provided by plants is due to the presence of a group of secondary metabolite compounds found in the plants. The types of secondary metabolite compounds are flavonoids, tannins, alkaloids and saponins. Chromolaena odorata L. contains tannins, phenols, flavonoids, saponins and steroids, while Pachyrhizus erosus L. is known to contain flavonoids and saponins. This study aimed to determine the gasprotective activity of the combination of Chromolaena odorata L. and Pachyrhizus erosus L. extracts in ethanol-induced rats by observing the parameters of the number of peptic ulcers, protection ratio, and images of gastric histopathology. The research method was to make a combination of Chromolaena odorata L. and Pachyrhizus erosus L. extracts which were given to six treatment groups: normal group without treatment; negative control group; positive control group given sucralfate; and three groups given a combination treatment of Chromolaena odorata L. and Pachyrhizus erosus L. extract with a dose of 100, 200, and 400 mg/kgBW. Treatment was done by oral administration for 14 days. On Day 14, after one hour of treatment, 96% ethanol induction was given orally at a dose of 2 ml/200 gBW except for the normal group. The ulcer index produced by negative control, positive control, the treatment with doses of 100, 200, and 400 were 4.18; 2.98; 2.49; 1.64; and 0.78, respectively. The combination of Chromolaena odorata L. and Pachyrhizus erosus L. extracts can prevent gastric damage in rats caused by ethanol induction.