The research aimed to find out whether there was interaction between fermentation duration and probiotics dose toward the increase in crude protein and decrease in crude fiber content in coffee peel. This research was experimental using complete randomized design (RAL) factorial, data analysis using duncan. The result of the research showed that there was interaction between duration and probiotics doses in coffee peel fermentation to crude protein in day 5 of fermentation duration with probiotics dose of 5%, it was the highest result of crude protein content. There was no interaction between duration fermentation and probiotics dose in fermentation of coffee peel toward crude fiber content in day 7 duration of fermentation with probiotics dose of 5%, it was the result of the lowest crude fiber. Fermentation in 7 days with dose of 5% was the best result. There was increase of protein from 12.15% to 13.93% and decrease of fiber from 34.27% to 30.8%.

Two isoprenylated flavanones  namely as lonchocarpol A (1)  dan lupinifolin (2) were isolated from  the stem bark of Limonia accidissima L. Erythrina fusca L. Their structures were determined  based on spectroscopic data such as UV, IR, MS and NMR. Compounds 1–2 were evaluated for their antimalarial against Plasmodium falciparum strain 3D7 showing their IC50 were 1.18 and 0.8 µg/ml, respectively and very high activity.

ABSTRAK Dua senyawa flavanon terisoprenilasi yakni lonkokarpol A (1) dan lupinifolin (2) telah diisolasi dari kulit batang Erythrina fusca L. Struktur senyawa flavanon terisoprenilasi ditetapkan berdasarkan analisis spektroskopi UV, IR, MS dan NMR. Uji aktivitas antimalarial senyawa 1–2 terhadap Plasmodium falciparum strain 3D7 memperlihatkan IC50 1,18 dan 0,82 µg/ml yang dikategorikan sangat aktif. Kata kunci : Erythrina fusca L., lonkokarpol A, lupinifolin, antimalaria ABSTRACT Two isoprenylated flavanones namely as lonchocarpol A (1) dan lupinifolin (2) were isolated from the stem bark of Limonia accidissima L. Erythrina fusca L. Their structures were determined based on spectroscopic data such as UV, IR, MS and NMR. Compounds 1–2 were evaluated for their antimalarial against Plasmodium falciparum strain 3D7 showing their IC50 were 1.18 and 0.8 µg/ml, respectively and very high activity. Keywords : Erythrina fusca L., lonchocarpol A, lupinifolin, antimalarial