Objective The objective of the study is to find the effect of jaundice during pregnancy on fetomaternal outcome over a 10-year period at tertiary care hospital. Materials and methods An analysis of fetomaternal outcome of all case records with jaundice in pregnancy from January 2003 to December 2013 is made. Results The incidence of jaundice in our study is one in 278 pregnancies, with the disease more common in younger age group. Viral hepatitis found to be the commonest cause, HEV being the commonest with a high maternal and perinatal mortality. Obstetric cholestasis being the second most common followed by HELLP syndrome, AFLP and sepsis; Hepatorenal failure, encephalopathy, DIC and PPH were the main causes of maternal mortality. Conclusion Viral hepatitis is most prevalent cause of jaundice in pregnancy, associated with a high maternal and perinatal mortality and morbidity. How to cite this article Ambreen A, Ahmed F, Sheikh A, Ayub MR, Faryad N, Mushtaq S. Jaundice in Pregnancy: A Clinical Study at Fatima Memorial System. J South Asian Feder Obst Gynae 2015;7(1):22-25.

The rationale of our study is to investigate whether aspirin alone, or aspirin combined with low molecular weight heparin as compared to placebo (intensive pregnancy surveillance), would improve the live birth rate (primary outcome) among with idiopathic recurrent miscarriages. Secondary outcomes included rate of serious adverse events during pregnancy among pharmacological intervention group and intensive surveillance group: rates of miscarriage, intrauterine fetal death (fetal death after 24 weeks of gestation), small for gestational age, premature delivery, APH and PPH. Study Design: A prospective, randomized, single-blinded, placebo-controlled trial was conducted at Tertiary Referral Obstetric Hospital. Setting: Fatima Memorial Hospital, Lahore Period: 2007 to 2013. Method: The participants were 172 women with a diagnosis of idiopathic recurrent miscarriage.12 patients dropped out of the study. Women with 2 or more recurrent fetal losses and after exclusion of all known causes of recurrent miscarriage were randomly allocated to receive aspirin alone (n=54), combination treatment aspirin and heparin (n=56) or placebo (n=50 intensive pregnancy surveillance). The results were analyzed by SPSS (version 17) and they were tested by chisquare test. Results: Out of 160 women who underwent randomization, live birth rate did not differ significantly among the three groups. The live birth rate was 70.3% among aspirin only group, 73.2% among aspirin and heparin group and 70% among intensive surveillance group (placebo) with a p value equal to 0.11. No significant differences in secondary outcome were observed among three groups. Conclusion: In conclusion, our findings do not support the hypotheses that use of aspirin alone or in combination with enoxapirin improves the live birth rate in women with idiopathic recurrent miscarriages.

Objectives: The rationale of our study is to investigate whether aspirin alone,or aspirin combined with low molecular weight heparin as compared to placebo (intensivepregnancy surveillance), would improve the live birth rate (primary outcome) among withidiopathic recurrent miscarriages. Secondary outcomes included rate of serious adverse eventsduring pregnancy among pharmacological intervention group and intensive surveillance group:rates of miscarriage, intrauterine fetal death (fetal death after 24 weeks of gestation), small forgestational age, premature delivery, APH and PPH. Study Design: A prospective, randomized,single-blinded, placebo- controlled trial was conducted at Tertiary Referral Obstetric Hospital.Setting: Fatima Memorial Hospital, Lahore Period: 2007 to 2013. Method: The participantswere 172 women with a diagnosis of idiopathic recurrent miscarriage.12 patients dropped outof the study. Women with 2 or more recurrent fetal losses and after exclusion of all knowncauses of recurrent miscarriage were randomly allocated to receive aspirin alone (n=54),combination treatment aspirin and heparin (n=56) or placebo (n=50 intensive pregnancysurveillance). The results were analyzed by SPSS (version 17) and they were tested by chisquaretest. Results: Out of 160 women who underwent randomization, live birth rate did notdiffer significantly among the three groups. The live birth rate was 70.3% among aspirin onlygroup, 73.2% among aspirin and heparin group and 70% among intensive surveillance group(placebo) with a p value equal to 0.11. No significant differences in secondary outcome wereobserved among three groups. Conclusion: In conclusion, our findings do not support thehypotheses that use of aspirin alone or in combination with enoxapirin improves the live birthrate in women with idiopathic recurrent miscarriages.

Objective To assess the prevalence of mood depression and anxiety in women with prospectively diagnosed polycystic ovary syndrome (PCOS). Materials and methods A cohort study at Fatima Memorial Hospital was conducted with a total of 137 patients with PCOS and a similar number of controls, attending gynecology clinic; all participants of the study were required to complete hospital anxiety and depression scale (HADS) questionnaire. Later the biochemical assessment was done between PCOS with depression to PCOS without depression in order to find its associates. Results Study shows an increased prevalence of depression and anxiety in women with PCOS as compared to control, general population. How to cite this article Batool S, Ul ain Ahmed F, Ambreen A, Sheikh A, Faryad N. Depression and Anxiety in Women with Polycystic Ovary Syndrome and Its Biochemical Associates. J South Asian Feder Obst Gynae 2016;8(1):44-47.