This study aims to identify the student perceptions of interactive multimedia applications in teaching and learning process in 21st century. Interactive multimedia is an integration of five elements (text, graphics, video, audio, and animation). The study design used was a quantitative survey by using questionnaire as instrument. Data was analyzed through quantitative and descriptive approach. The respondents were selected among 30 form 1 students that selected by purpose sampling technique to answer the objectives of the study. The result shows that majority students gave a positive perception to the applications of interactive multimedia in teaching and learning in the classroom. This method can improve a student’s concentration level and easily understand the subject matter. In conclusion, teachers should know that the applications of interactive multimedia in teaching and learning can gain positive impact not only to the skills of the information and communication technology by the teacher itself that can diversify the teaching method, but at the same time can produce a creative, innovative, smart students in both IT and knowledge.

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