Background: Obesity is a cause of FGF21 resistance, which affects the browning and thermogenesis process of the adipose tissue. Decreased receptor expression is influenced by miR-34a, whose expression is increased in obesity. While FGF21-based therapies have been widely investigated, the potential activity of Hibiscus sabdariffa Linn. extract (HSE) against FGF21 resistance is unknown.Objective: This study aims to determine the effects of HSE on the expression of miR-34a and FGF21 receptors in white adipose tissue.Methods: This experimental study used 24 male Sprague-Dawley rats and divided into four groups: Control (N); diet-induced-obesity rats (DIO); DIO rats with HSE 200 mg/kgBW/day and DIO rats with HSE 400 mg/kgBW/day. Rats were fed a highfat diet for 17 weeks. HSE was administered daily for 5 weeks. The administration of HSE 400 mg/kgBW/day resulted in the equivalent expression of miR-34a to that of the control (p > 0.05).Results: FGFR1 receptor expression was also similar to controls (p > 0.05). Beta-klotho expression was significantly lower than that of control (p < 0.05) but equivalent to that of DIO rats (p < 0.05). Conclusions:H. sabdariffa has the potential to reduce FGF21 resistance in DIO rats through the suppression of miR-34a expression and an increase in the number of FGFR1 and beta-klotho receptors in adipose tissue.

Background Obesity is a cause of Fgf21 resistance, which affects the browning and thermogenesis process of the adipose tissue. Decreased receptor expression is influenced by microRNA 34a (miR-34a), whose expression is increased in obesity. While Fgf21-based therapies have been widely investigated, the potential activity of Hibiscus sabdariffa Linn extract (HSE) against Fgf21 resistance is unknown. This study aims to determine the effects of HSE on the expression of miR-34a and Fgf21 receptors in white adipose tissue. Methods This experimental study used 24 male Sprague-Dawley rats and divided into four groups: Control (N); diet-induced-obesity rats (DIO); DIO rats with HSE 200 mg/kgBW/day and DIO rats with HSE 400 mg/kgBW/day. Rats were fed a high-fat diet for 17 weeks. HSE was administered daily for five weeks. The administration of HSE 400 mg/kg BW/day resulted in the equivalent expression of miR-34a to that of the control (p > 0.05). Results Fgfr1 receptor expression was also similar to controls (p > 0.05). Beta-klotho expression was significantly lower than that of Control (p < 0.05) but equivalent to that of DIO rats (p < 0.05). Conclusions H. sabdariffa has the potential to reduce Fgf21 resistance in DIO rats through the suppression of miR-34a expression and an increase in the number of Fgfr1 and beta-klotho receptors in adipose tissue.

Tujuan: Penelitian ini untuk mengetahui hubungan indeks massa tubuh (IMT) terhadap craniovertebral angle (CVA) pada pekerja  back office.Metode : Penelitian ini merupakan penelitian observasional.  Penelitian ini bersifat deskriptif kuantitatif dengan tipe studi korelasi. Sampel dipilih menggunakan teknik purposive sampling didapatkan 30 karyawan RSUP X Jakarta dimana IMT dihitung berdasarkan rumus berat badan dibagi kuadrat tinggi badan sedangkan CVA diukur dengan skor photogrammetry. Hasil : Pada penelitian ini rerata dan simpangan baku IMT adalah  26,88±3,98 dan nilai derajat CVA yaitu, 39,88±4,66. Uji normalitas dengan kolmogorov smirnov test didapatkan data berdistribusi normal. Hasil uji hipotesis dengan uji statistik korelasi pearson product moment, didapatkan p < 0,0001 pada IMT  dan CVA serta nilai r = -0,731 maka terdapat korelasi positif antara IMT dengan CVA. Kesimpulan : Terdapat korelasi positif antara nilai  IMTterhadap nilai CVA yang menunjukkan semakin tinggi IMT maka nilai rerata CVA sesuai kriteria FHP.

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