Aloe barbadensis leaves and Hylocereus polyrhizus are plants that are easily found in Malaysia. They arecommonly studied for antibacterial activity and how they can benefit the human being. However it is notknown about how the combination of both plants work to become the alternative way of remedies. Theobjectives of this study were to determine the antibacterial, antioxidant, and toxicity of Hylocereuspolyrhizus peels and Aloe barbadensis leaves extracts. The antibacterial activities were evaluatedtowards the bacteria commonly associated with skin infections; which are Staphylococcus aureus,Propionibacterium acnes and Pseudomonas aeruginosa, using Kirby-Bauer Disc Diffusion method. Theantioxidant activity was determined using DPPH assay. The toxicity activity was evaluated by exposingthe extracts towards brine shrimp. As for the results, Aloe barbadensis extracts showed the highestantibacterial activity compared to Hylocereus polyrhizus and the combination of both extracts. For theantioxidant activity and the toxicity test, Hylocereus polyrhizus possessed the best result, where the IC50obtained was 226.397 μg/ml and LC50 was 28588.76 μg/ml (non-toxic). In conclusion, Aloe barbadensis,Hylocereus polyrhizus and the combination of both have the potential to become alternative way asremedies instead of modern medicines.  Keywords: Hylocereus polyrhizus, Aloe barbadensis, antibiotics, antioxidants, toxicity.