Melioidosis, an infectious disease caused by Burkholderia pseudomallei, has recently gained importance as an emerging infectious disease in Indonesia. Reports of this infection in Indonesia are limited, although cases have been reported in Makassar, South Sulawesi. We report a case of cutaneous melioidosis caused by pan-drug-resistant, moderate biofilm-producer strain of B. pseudomallei in a diabetic patient. To the best of our knowledge, this is the first case of melioidosis caused by multidrug resistant and biofilm-former strain of B. pseudomallei being reported from Yogyakarta Province, Indonesia. The patient was successfully treated with abscess drainage and debridement, including total contact casting and no antibiotic treatment.

Introduction: Diabetes is a non-communicable disease with incidence rate of about 1.5 – 2.3% per annum with the most complication is Diabetic Foot Infections (DFIs). Objective: This research was conducted to describe the bacteria responsible for biofilm formation and its ability to cause DFIs in biofilm formation at Dr. Sardjito General Hospital as well as the therapy outcome. Methods: This research was conducted from September to November 2017. Specimens of samples were obtained from wound swabs of DFIs patients who met the inclusion and exclusion criteria (31 outpatients and 15 inpatients), and were then tested for culture and sensitivity and their ability to form biofilms. Results: The DFIs with the biofilm-producing bacteria (weak to moderate) have a different outcome compared to DFIs patients without biofilms.

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