Background: Traditional medicine had been used alongside synthetic pharmaceutical products to enhance health management. Due to the high mortality rate of sickle cell patients, previous studies have been indicated that some medicinal plants have shown an anti-sickling activity, which indicates a new therapeutic way to manage people who are affected by these disorders. The current study aimed to assess in vitro-anti-sickling activity of Hyphaene thebaica (H thebaica) (Doum) fruit. Materials and methods: Blood samples used in the evaluation of the anti-sickling activity of Hyphaene Thebaica Fruits extract in this study was taken from patients known to had Sickle cell disease (HB -SS ) attending the Sickle Cell Clinic in Khartoum state. Emmel test was used to assess anti-sickling activity of this plant. Result: A significant increase in the percentage of unsickled Red blood cells with p-value 0.05 >was observed after incubation of RBCs with 2% sodium metabisulfite in the presence of three different concentration (1000, 500 and 250) μg/ml of Hyphened thebaica for two type of extraction (aqueous and methanol) extract. Conclusion: This study approved that H.thebaica (Doum ) fruit extract had a strong anti- sickling activity ; it could be used for management of sickle cell disease.

Background: Sickle cell disease is one of the major haemoglobinopathies affecting African people, in Sudan many children are suffering from this disease. Numerous studies revealed that some medicinal plants have shown an antisickling activity, which may be a new therapeutic way to a range of people who are affected by this disease. Particularly that, chemical treatment is cost effective and has many side effects. The study aimed to evaluate in vitro antisickling effect of Moringa Oliefera on sickle cells.Materials and methods: Using seeds and leaves crude (methanol extract and aqueous extract), the in vitro antisickling activities of Moringa oleifera fractions, were evaluated using erythrocyte cells deoxygenated with 2% sodium metabisulphite. Normal saline was employed as an internal negative control.Results: All extracts revealed high anti sickling activity in deoxygenated erythrocytes (P < 0.05) when compared with the negative control.Conclusions: Findings from the present study suggest the antisickling potential of the seeds and leaves of Moringa oleifera.