Introduction. Based on the literature data and directive documentation, the main reasons for the use of alternative methods for determining the toxic effects of perfume and beauty products are set out. Methods — alternative methods based on toxicity assessment using short-term suspension culture of cells of cattle spermatozoa. The toxicological prognosis of the alternative method according to the results of studies is close to the significance of the toxicological prognosis obtained in the experiment with the use of laboratory animals. Mobility is an integral parameter of the physiological, biochemical and morphological status of the short-term suspension culture of mammal cells cattle spermatozoa. Conclusion. The argument for the implementation of alternative methods for determining the toxic effect of perfume and beauty products (PBPs) is aimed at the humane attitude towards animals, as well as reducing costs and reducing the time spent on the study. Key words: toxicity, perfume and beauty products, alternative methods, spermatozoa, cattle.

Aim. To summarize and outline the major risks from using glass cleaners based on literature data and own research work. Methods. Several series of odorimetrical. sanitary and chemical studies have been carried out under various modeling conditions, analytical methods of examination have been applied to determine the main functional components. Conclusions. Under the compliance with manufacturer recommendations for using, investigated modern household glass cleaners made on the basis of ethyl or isopropyl alcohol, can be referred to the low risk products for human health. Key Words: glass cleaners, alcohols, risk degree.

The aim of the Research. To study the content of toxic elements (lead, arsenic and mercury) in decorative cosmetics. Methods and Materials. The study included lipsticks, mascara, children’s decorative cosmetics from domestic and foreign manufacturers (Ukraine, Finland, France, Latvia, Japan) and pigments used in manufacturing. The content of toxic elements was determined using inductively couple plasma atomic emission spectrometry on JCPE-9820-2015 device. Advanced mathematical and statistical methods were applied to analyze the findings of the study. Results and Discussion. The findings of the study indicate that decorative cosmetics products in the Ukrainian market may contain lead and arsenic concentration resulting in undesirable health outcomes. Conclusions. The study on toxic elements contents in decorative cosmetics products proves the necessity for these products mandatory control by the given indicators. Thorough sanitary and chemical control over their production and selling will prevent access of low quality and hazardous to human health cosmetic products to the Ukrainian market. Key Words: decorative cosmetics, hazard, lead, arsenic and mercury concentration.

Introduction: Due to introduction of new forms of agriculture and transformation of the treatment and preventive service in recent years, there has been a false impression of a sharp decrease in the level of occupational morbidity among agricultural workers 30 % to 25 % in the structure of general occupational morbidity in the 80–90s down to 0.2-0.4 %. The aim: Summarize data on the prevalence, causes, structure of acute pesticide poisoning in agricultural workers at the current stages of its reform in order to improve preventive measures. Materials and methods: Data on the prevalence, causes and structure of 647 cases of acute pesticide poisoning in agricultural workers over the past 25 years have been summarized; staff of the Scientific Toxicology Center took part in the sanitary-hygienic investigation and establishment of the diagnosis. Results: The causes for the development, aetiology and structure of 647 cases of acute pesticide poisoning, among which 522 cases of acute poisoning of field beet growers with 2,4-D-based herbicides (80.7 %), 60 cases (9.3 %) of OPC poisoning, 36 cases of beet growers poisoning with sulphonylurea-based herbicides, 14 patients with acute synthetic pyrethroid poisoning, and isolated cases (15 patients) of intoxication with aluminium phosphide, dithiocarbamates, Vitavax, and Fipronil were analysed. Conclusions: Analysis of the causes of the development and structure of poisoning has allowed to optimize the complex of preventive measures to strengthen sanitary control over the implementation of individual and public safety hygienic regulations during storage and use of pesticides.