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In the past geological eras in the bio-sphere, species extinction was accompanied by speciation. Ecosystems adapted to a greater or lesser extent to coexist with a species whose activity had become a plane-tary factor and had a global impact on bio-spheric processes. One of it is the massive pollution of the main components of the biosphere - geobiosphere, hydrobooster and air. Its consequence is the development in living organisms of various pathological processes associated with the impact of tox-icants-toxicoses. The work was carried out in various re-gions of the USSR and Russia on reservoirs of various types and different objects of aquaculture. Various species and age groups of fish were studied. They were caught with trawls, nets, lifts, and sport fishing gear. Fish larvae were caught with a plankton net. A pathoanatomic method was used to assess the condition of fish. In some cases, histo-logical methods were used. Clams of the family Unionidae were surveyed in 1990-2011. They were collected by dredging in the reservoirs of the Volga, in the lake Ilmen, in the red sea of the Ka-relian isthmus of the Leningrad region and in the Gulf of Finland of the Baltic sea. The liver of 399 individuals was examined us-ing histological methods. Also Perlovitz. Unio pictorum, 474 copies of U. tumidus and 298 copies. the mussels Anodonta sp. Branched crustaceans were examined in 1989-2016. They were collected in a plank-ton grid in the reservoirs of the Volga, in the Nyvchimsky reservoir (the basin of the Volga river). Vychegda Komi Republic, in the Finnish and Kursk bays of the Baltic sea, in lake Ladoga, in the lake of Sevan (Armenia) and in lakes of the Karelian isth-mus of Leningrad region, in the mountain lakes of West Sayan (Krasnoyarsk region), the lakes in Darwin reserve (Vologda re-gion) and in the pools of Garbacki lakes Bolshezemelskaya tundra (Vorkuta district, Komi Republic). Fixation in 4% formalin by Rachkov method was examined in Bo-gorov's cell under the MBS-9 microscope.