These observations were made with the object of determining whether the vitally staining reticulation of young erythrocytes persists or is lost in blood preserved in vitro. In this manner it was hoped to gain some further information concerning the effect of such preservation on the erythrocyte from the point of view of the value of such cells for transfusion purposes. If it could be shown that preservation of erythrocytes in vitro for several weeks or a month did not reduce the percentage of cells in which the reticulation could be demonstrated

IntroductionSarcoidosis is a multisystemic granulomatous disease with diverse and often non-specific symptoms during childhood. The clinical manifestations sometimes include endocrinopathies related to sarcoid infiltration of various endocrine organs, but more commonly due to the associated autoimmune endocrine disorders. There are only a few reports of multiple autoimmune and non-autoimmune endocrine problems occurring simultaneously in patients with sarcoidosis. We report a girl with probable sarcoidosis who also had Hashimoto’s thyroiditis, Type 1 diabetes (T1D) and secondary adrenal insufficiency.Case PresentationA 9-year-old girl previously diagnosed with autoimmune hypothyroidism and vitamin D deficiency, presented with hypercalcemic pancreatitis after initiating vitamin D supplementation that lead to a diagnosis of probable sarcoidosis. Secondary adrenal insufficiency and T1D were subsequently diagnosed. Her angiotensin converting enzyme levels on 2 occasions were 106 and 135 nmol/mL/min (normal range 10 - 43). All investigations conducted to exclude several infectious and malignant conditions that may mimic sarcoidosis were negative. The patient showed a good response to treatment with hydrocortisone, levothyroxine, insulin and methotrexate.ConclusionsTo our knowledge, ours is the youngest ever patient reported in the literature with sarcoidosis to develop multiple autoimmune and non-autoimmune endocrinopathies.

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Subcutaneous experiments with the albino rat demon¬ strated that the addition of 2.5 per cent, procain to the magnesium sulphate solution (50 per cent.) or to the magnesium sulphate solution with morphin increases the efficiency, definitely prolongs the effect, and allays irritation, without increasing toxicity. The synergism between magnesium sulphate and procain is definite because procain in itself produces no general analgesic action when injected subcutaneously in the albino rat. The addition of 2.5 per cent, procain increased the efficiency of the magnesium sulphate approximately 50 per cent. The combination of magnesium sulphate (50 per cent.) with procain (2.5 per cent.) may be a

In this communication we present the results of a study of the metabolism, before and after splenectomy, in a child 5 years of age suffering from congenital hemolytic icterus with splenomegaly. As Dr. S. McC. Hamill, to whom we are indebted for the opportunity of making these studies, will, in a later communication, offer a consideration of the clinical and therapeutic problems involved, we will, aside from the metabolic studies, present only a brief abstract of the clinical history, a note on the pathology of the removed spleen and a table (Table 1) of the blood examinations before and after operation.