Burns (combustio) - tissue damage arising from thermal, chemical, electrical or radiation exposure. Burn disease – a complex violation of the organs and systems, developing due to extensive burns. The cause of burn disease is the loss of all types of the skin functions, loss of plasma, the collapse of red blood cells, as well as metabolic disorders. The probability of development, severity, and prognosis in this pathology are determined by the age of the patient, the General condition of his body and some other factors, but the leading role is played by the area of the lesion. 500 thousand animals are burned according to statistics in Russia for the year, and as a rule, mortality among burned animals is more than 11%. Treatment includes antibiotic therapy, infusion, and detoxification therapy, correction of all organs and systems. Treatment of burns of the first and second degree is most often limited to the local use of drugs that reduce pain sensitivity, promote faster tissue regeneration and help prevent infection, which leads to lengthening of healing processes and other complications. In the case of third and fourth-degree burns, regular thorough cleaning of the affected areas is also necessary, sometimes surgical intervention is required. Today, burns are widespread, so the search for effective treatments remains relevant. In this paper, we describe the etiology, pathogenesis of burns of small pets, the definition of the most effective and cost-effective method of treatment. The task of the research was also to determine the degree of burns and diagnosis of burns.

This review article deals with the comparison of different modes of anticoagulant therapy, taking into account the risk profile and the individual characteristics of patients with atrial fibrillation. This paper analyzes the efficacy and safety of direct oral anticoagulants in different clinical situations. Modifiable and unmodifiable bleeding risk factors are evaluated based on the hemorrhagic complication risk assessment scales for patients taking anticoagulants. The evidence base for anticoagulant therapy in the presence of a single episode of atrial fibrillation is represented. Regimens and terms of initiation of anticoagulant therapy after a cardioembolic stroke or transient ischemic attack are considered. In addition, great attention is paid to the problem of early prescription of anticoagulants after intracranial hemorrhage. For patients at high risk of gastrointestinal bleeding or impaired renal function, an optimal strategy for reducing thromboembolic complications is evaluated. Anticoagulant therapy is also evaluated in patients with stable coronary heart disease, including after coronary stenting.