There are three groups of patients with abnormalities of magnesium homoeostasis. The first one include patients with magnesium deficiency (low total body magnesium content) and a resultant hypomagnesaemia (low serum magnesium concentration). Patients with hypomagnesaemia (serum magnesium concentration <0.75 mmol/L) in the absence of magnesium deficiency (i.e., a normal total body magnesium content) consist the second group. The third group include patients with magnesium deficiency (low total body magnesium content) but no evidence of hypomagnesaemia (i.e., a normal serum magnesium concentration). Magnesium deficiency can be caused by decreased magnesium intake from the diet, decreased magnesium absorption, or increased renal magnesium excretion (renal magnesium wasting). The narrative review examines the causes, clinical and laboratory signs of magnesium deficiency in the body, and the effect of magnesium supplementation on health indices. Groups of people who are more likely to suffer from magnesium deficiency are outlined. Emphasis is placed on the use of questionnaires to identify individuals with possible magnesium deficiency. The changes on the electrocardiograms that are characteristic of the initial magnesium deficiency and that occur in case of its increase are given. The effect of additional intake of magnesium salts on blood pressure changes in individuals with and without baseline hypertension is discussed in detail. Factors that make it difficult to assess the relationship between magnesium intake and abnormalities in lipid and carbohydrate metabolism are listed. An association between increased dietary magnesium intake and reduced risk of certain cardiovascular diseases, diabetes mellitus, and overall mortality has been demonstrated. Keywords: hypomagnesaemia, blood pressure, diabetes mellitus.

При обстеженні 40 хворих з ерозивним гастродуоденітом у поєднанні з гіпертиреозом виявлений синдром хронічного ендотоксикозу, розвиток якого обумовлений надлишковим утворенням антитиреоїдних антитіл, малонового діальдегіду та поглибленням цитокінового дисбалансу. Доведена ефективність лікувальної тактики, що була спрямована на відновлення цитокінового балансу та застосування детоксикаційної терапії ентеросорбентом із високою сорбційною ємністю.

The aim of the research is to increase the effectiveness of preoperative diagnosis of patients with thyroid tumors and to assess the use of cancer-embryonic antigen and immunocytochemical research. Materials and methods: Patients were interviewed about their complaints and lifestyle; performed ultrasound with fine-needle aspiration, determination of the level of cancer-embryonic antigen (CEA), cytological and immunocytochemical researches. Results: The Benign process in the thyroid gland is low serum REA (less than 0.95 ng / ml), poor expression of thyroglobulin (77.8%), negative reaction with TTF-1 (100%) and cytokeratin-19 (55.6%). Differential-prognostic markers of thyroid neoplasms with risk of malignancy include increased serum REA (0.95 ng / ml and above), the presence of a moderate reaction with antibodies to thyroglobulin (80.0%), a positive reaction — to TTF-1 (100.0%) and E-cadherin (90.0%), with moderate or strong expression of cytokeratin-19 (90.0%). Statistically significant markers of malignant thyroid disease were determined: the presence of harmful factors at work (45.5%), smoking (27.3%), elevated serum REA (0.95 ng / ml and above), the presence of strong cytoplasmic expression of thyroglobulin (63.6%), moderate or strong expression of TTF-1 (90.9%) and cytokeratin-19 (81.8%). Conclusions: The most appropriate and practically significant for preoperative diagnosis of thyroid tumors is a set of several diagnostic methods, which are carried out in one hospital – ultrasound with fine-needle aspiration, cytomorphological, and immunocytochemical and REA levels in a primary screening.

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