In the present study, chlorogenic acid (CGA) isolated from Anfhocephalus cadamba was screened for hepatoprotective activity by in uifro and in uiuo assay methods using carbon tetrachloride (CCI,) as a model of liver iqjury. Intraperitoneal administration of CGA to mice at a dose of 100 mgkg body weight for 8 days caused significant reversal in lipid peroxidation, enzymatic leakage, cytochrome P450 (Cyt P450) inactivation and produced enhancement of cellular antioxidant defence in CC4-intoxicated mice, revealii that the antioxidative action of CGA is responsible for its liver protective activity. CGA exhibited a better therapeutic protective action than silymarin (SM), in CCl.,-administered mice.

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