The article considers the changes taking place with the personnel potential of industrial enterprises in Omsk under conditions of digitalization of the economy, analyzes certain indicators of the personnel potential of the region: dynamics of demographic indicators, personnel data and needs for specialists, compliance of the level of qualifications and education with the requirements of the economy. The relevance lies in the possibility of increasing the effective development of the personnel potential of enterprises based on active actions by all participants in the regional market in modern conditions of digitalization. General scientific methods of comparison, analysis and generalization are used